Metabolomic Core



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The Metabolomic Core at CHOP (MC@CHOP) provides analytical services to advance understanding of metabolism in health and disease states. The Core’s state-of-the-art research facility allows investigators to carefully study the relationship between metabolome, fluxome, and disease states such as cancer, diabetes, inborn errors of metabolism, metabolic syndrome, urea cycle defects, traumatic brain injury, drug addiction, and sleep disorders, and more. MC@CHOP provides the analytical and theoretical wherewithal to investigate the impact of drugs on metabolism as well as the potential benefits and risks of a given drug treatment.

The MC@CHOP staff includes scientists and research associates with more than 20 years of experience in operation of various mass spectrometry systems, high-performance liquid chromatography systems, enzyme assays, and data analysis.

We provide investigators with a state-of-the -art resources that facilitate experimental and technical consultations as well as analysis of metabolites and metabolic pathways in humans and animal models, both in vivo and in vitro systems, to establish a better understanding of metabolomic and fluxomic statuses as well as understanding drug handling and mechanism of action.