IDDRC Preclinical Models Core

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The Preclinical Models Core (PMC) was developed in response to a user survey that emphasized a need for an intellectual and developmental disabilities-focused facility for the study of mammalian behavior and one to address the potential of current stem cell technologies, including genome editing using CRISPR-Cas9.

The Rodent Behavioral Testing Service is provided by the Neurobehavior Testing Core at the University of Pennsylvania. Approved Intellectual and Developmental Disabilities Research Center users receive about a 15 percent discount for these services.

  • Customized behavior battery design
  • Consultation in experimental design and interpretation of results
  • Tests of learning and memory, affective disorder-related behaviors, social and communication tasks, neurodegeneration and sensation
  • Protocol and transfer assistance (IACUC, ULAR, and LAR)
  • Training in all procedures
  • Drug delivery
  • Tissue preparation
  • Video image analysis
  • Data analysis

The Human Pluripotent Stem Cell Service provides free consultation to approved Intellectual and Developmental Disabilities Research Center users.

  • Generate and characterize induced pluripotent stem cells (iPSCs)
    • Make them available to the research community
  • Differentiate PSCs
    • Mesodermal, endodermal, ectodermal lineages
  • Genetically manipulate PSCs
    • Transgene expression: Zinc finger nucleases
  • Gene editing PSCs
    • Gene loci: CRISPR/Cas9
  • Distribute NIH-approved human ESC lines
  • Distribute quality tested specialty reagents
  • Enrichment training

 

Leader

Zhaolan (Joe) Zhou, PhD