High Throughput Sequencing Core

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The High Throughput (HTS) Sequencing Core is a full-service facility providing instrumentation, library preparation, and sequencing services to Children’s Hospital of Philadelphia, University of Pennsylvania, and external investigators in genomic, epigenomic, and transcriptomic studies. Our goal is to make the HTS Core accessible to everyone interested in genomic studies. The HTS Core provides next-generation sequencing (NGS) services using Illumina® NGS technology. The facility operates several Illumina platforms: NovaSeq™ 6000, NextSeq™ 1000, and MiSeq™ V2 sequencing analyzers. 

The HTS Core has capabilities ranging from highly focused analysis of target DNA amplicon sequencing and miRNAs to whole genome, epigenome, exome, and transcriptome sequencing. Services are available for a diversity of study designs; starting from a few samples to large projects involving hundreds of samples, we are working with investigators to provide optimized and customized protocols for each study. The Core develops new applications to accommodate state-of-the-art next-generation sequencing technologies.

Project submissions and pricing information are available through the HTS Sequencing Core iLab portal.