Engineered CRISPR/Cas Systems as Novel Diagnostics and Therapeutics

Cell and Gene Therapy Center Special Seminar 

Engineered CRISPR/Cas Systems as Novel Diagnostics and Therapeutics

Faculty candidate:
Piyush K. Jain, PhD
Assistant Professor
University of Florida
Department of Chemical Engineering

Dr. Jain is known for the development of light-activated RNA interference (LARI) for the treatment of cancer and for creating an insulin photoactivated depot (PAD) for the treatment of type I diabetes.

As a postdoctoral associate at MIT, Dr. Jain with his team developed photoactivatable protease nanosensors for more reliable cancer detection in the urine and also led the development of CRISPR-plus (CRISPR-precise light-mediated unveiling of sgRNAs) technology that allows control of CRISPR activity with light. All these advanced systems present approaches to control biological processes with light in a spatiotemporal manner. In addition, Dr. Jain developed a targeted delivery system for CRISPR/Cas systems known as CRISPR-GPS using tandem peptide-lipid constructs.

The Jain lab is currently interested in improving the efficiency and specificity of CRISPR/Cas technologies and on developing targeted delivery of nucleic acids and proteins for efficient CRISPR-mediated genome editing. The long-term goal  is to translate these systems into better disease diagnosis and treatment of genetic disorders for patients.

Host

Beverly Davidson, PhD
Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Research Vector Core

Please e-mail webber@chop.edu if you would like to meet with the speaker.

Join

To join, please visit: https://bluejeans.com/867762781