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CCMT Seminar Series - March 9
The Raymond G. Perelman Center for Cellular and Molecular Therapeutics at CHOP presents a Lecture Series:
A Stressful Beginning: DNA Replication in the Mammalian Embryo
Dieter Egli, PhD
Associate Professor of Cell and Developmental Biology
Department of Pediatrics
Naomi Berrie Diabetes Center
Columbia Stem Cell Initiative
Department of Obstetrics and Gynecology
Description of Research
DNA replication is not usually thought of as a cell-type specific process because of a constant result, the duplication of the entire genome. Cellular phenotypes are generally viewed through the lens of transcriptional differences, rather than differences in DNA replication. However, genome integrity is required for cell cycle progression, and there are both locus as well as cell-type specific differences in DNA replication and genome stability. The functional significance of these differences are still poorly understood. Dr. Egli will present progress on studies on DNA replication in the early mammalian embryo, and genomic methods of analysis of DNA replication.
Kai Wang, PhD
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