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CCMT Lecture Series 2021-2022 - March 3, 2022

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Date:
Mar 3, 2022 ‐ 11:00 am
End Date/Time-NEW
Where:
Location - People View
Room 5040

3501 Civic Center Blvd
Philadelphia, PA 19104
United States

The Raymond G. Perelman Center for Molecular Therapeutics at CHOP presents a Lecture Series:

"Control of Nervous System Wiring by Cell Surface Protein Interactions"

Speaker

Kai Zinn, PhD
Howard and Gwen Laurie Smits Professor of Biology and Biological Engineering
California Institute of Technology

Host

Yuanquan Song, PhD

Please email songy2@chop.edu if you would like to meet with the speaker.

Description of Research

During the development of “hard-wired” neural systems such as the Drosophila brain, interactions between cell adhesion molecules (CAMs) program synaptic connection patterns. Dr. Zinn’s lab conducted a global “interactome” screen for in vitro interactions among Drosophila immunoglobulin superfamily (IgSF) cell surface proteins, and discovered a network of 32 interacting CAMs in which 21 Dpr proteins in one IgSF subfamily bind to 11 DIP proteins in a second subfamily. Each DIP and Dpr is expressed on a specific subset of neurons in each area of the developing nervous system, and DIP::Dpr interactions are required for synaptic targeting and cell survival. Together with colleagues at Stanford, Dr. Zinn’s lab defined the larger human IgSF interactome and identified many new networks of proteins expressed in the immune and nervous systems.