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Emergence and Progression of AGT
This study is now recruiting.
The purpose of this research study is to test how people with cystic fibrosis process sugar and learn more about their risk of developing cystic fibrosis-related diabetes. We will also test the body's ability to make insulin in response to sugar.
This study requires 3 visits to the Main Hospital at CHOP. These visits will be repeated over the span of 5 years. Study participants will be screened to confirm eligibility. A DXA scan measures body composition and will be completed. You will also be asked to complete an Oral Glucose Tolerance Test (OGTT), a Mixed Meal Tolerance Test (MMTT), and a Glucose Potentiated Arginine test (GPA). A series of blood draws will be conducted during each procedure. An OGTT will require consumption of glucola, a sugary drink. The OGTT test measures how the body reacts to sugar and its susceptibility to diabetes. The MMTT will require coordination with a dietician for a meal as this procedure is looking at your body's response to food. The GPA requires infusion of sugar as well as a naturally occurring amino acid. This tests the body's ability to make insulin in response to sugar. All procedures require overnight fasting.