De León-Crutchlow Laboratory Research Studies

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Blood Sugar Stability in Individuals with Hyperinsulinism

The purpose of the study is to evaluate blood sugar levels and beta-cell function in adolescents and adult with KATP hyperinsulinism whom did not undergo pancreatectomy.

Related Conditions:
Hyperinsulinism, Genetic Disease, Endocrinology Disorders, Pediatric Endocrinology, Glucose Metabolism, Glucose Intolerance
This study is actively recruiting.

Dasiglucagon for the Treatment of Children with Congenital Hyperinsulinism (for children under 1 year of age)

Dasiglucagon for the Treatment of Children with Congenital Hyperinsulinism

This study is a randomized, double-blind, placebo-controlled study that will evaluate the safety and efficacy of dasiglucagon in children between the ages of 7 days and 12 months who have congenital hyperinsulinism.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Endocrinology Disorders, Insulin Dysfunction, Rare Disease, Rare Disorder Natural History Studies and Clinical Trials, Clinical Trials, Pediatric Endocrinology, Beta Cell Dysfunction, Rare Genetic Disorders, Pancreas Dysfunction
This study is actively recruiting.

DTX401 Gene Therapy in Glycogen Storage Disease (GSD) Type Ia

Our team at the Congenital Hyperinsulinism Center at CHOP is working on a research study to determine whether an experimental gene therapy product, DTX401, is safe and effective in people with glycogen storage disease type Ia (GSDIa)

Related Conditions:
AAV Vectors, Hyperinsulinism, Adeno-associated Viral Vectors, Viral Vectors, Hypoglycemia, Clinical Trials, Rare Disorder Natural History Studies and Clinical Trials, Endocrinology Disorders, Gene Therapy Research, Gene Transfer Therapy, Rare Disease, Diabetes and other Metabolic Diseases, Pediatric Endocrinology, Rare Genetic Disorders, Pediatric Genetic Disease, Genetic Disease, Genetic Mutations, Gene Therapy, Genetic Disorders, Metabolic Disease, Metabolic Disorders
This study is actively recruiting.

HM15136 for the Treatment of Congenital Hyperinsulinism Research Study

The purpose of this study is to look at the safety and tolerability (how well you will react) of the study drug (HM15136) and to determine if it is effective for the treatment of Congenital Hyperinsulinism (HI).

Related Conditions:
Hyperinsulinism, Hypoglycemia, Endocrinology Disorders, Clinical Trials, Beta Cell Dysfunction, Pediatric Endocrinology, Rare Disorder Natural History Studies and Clinical Trials, Rare Disease, Insulin Dysfunction, Pancreas Dysfunction, Beta Cell Dysfunction
This study is actively recruiting.

Phenotypes of Congenital Hyperinsulinism

Phenotypes of Congenital Hyperinsulinism

We are doing this study to see if the patterns of abnormalities in controlling insulin in children and adults with hyperinsulinism are related to any underlying genetic cause and to identify possible new genetic causes.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Endocrinology Disorders, Pancreas Dysfunction, Pancreatectomy, Genetic Disorders, Rare Disease, Rare Disorder Natural History Studies and Clinical Trials, Genetic Disease, Beta Cell Dysfunction, Pediatric Endocrinology
This study is actively recruiting.

Phenotyping Congenital Hyperinsulinism

Phenotyping Congenital Hyperinsulinism

The Congenital Hyperinsulinism Center at the Children's Hospital of Philadelphia is working on a research study to better understand how people with hyperinsulinism may have different blood sugar responses to certain tests (like fasting or drinking a high-protein shake) when compared to people without hyperinsulinism.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Insulin Dysfunction, Pancreas Dysfunction, Endocrinology Disorders, Glucose Metabolism, Glucose Intolerance, Genetic Disease, Rare Disease, Pediatric Endocrinology, Rare Disorder Natural History Studies and Clinical Trials
This study is actively recruiting.

Research Study for Individuals with Hyperinsulinism, Type 1 Diabetes Mellitus, and Healthy Children

Research Study for Individuals with Hyperinsulinism, Type 1 Diabetes Mellitus, and Healthy Children

Our team is working on a study to better understand neurological problems, including seizures and developmental delays, that occur in children with hyperinsulinism, including HI/HA syndrome, and type 1 diabetes mellitus.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Insulin Dysfunction, Pancreas Dysfunction, Endocrinology Disorders, Neuroendocrinology, Neuroimaging, Glucose Metabolism, Rare Disease, Rare Disorder Natural History Studies and Clinical Trials, Pediatric Endocrinology
This study is actively recruiting.

Research Study for Individuals with Hyperinsulinism/Hyperammonemia

This study is to better understand neurological problems, including seizures and developmental delays, that occur in many individuals with HI/HA syndrome.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Endocrinology Disorders, Pancreas Dysfunction, Pancreatectomy, Neuroendocrinology, Brain Function and Metabolism, Neurobiology of Disease, Neuroimaging, Glucose Metabolism, Glutamate Uptake, Rare Disease, Rare Disorder Natural History Studies and Clinical Trials, Pediatric Endocrinology
This study is not recruiting.

RIZE Clinical Trial for Individuals with Hyperinsulinism

RIZE Clinical Trial for Individuals with Hyperinsulinism

The goal of the trial is to test the study drug safety, how your body processes the drug, how the drug affects your body, and see if it can increase your blood sugar.

Related Conditions:
Hyperinsulinism, Hypoglycemia, Endocrinology Disorders, Clinical Trials, Beta Cell Dysfunction, Pediatric Endocrinology, Rare Disorder Natural History Studies and Clinical Trials, Rare Disease, Insulin Dysfunction, Pancreas Dysfunction, Beta Cell Dysfunction
This study is not recruiting.

UX053 in GSD III

Our team at the Congenital Hyperinsulinism Center at CHOP is working on a clinical drug trial that involves giving you a study drug called UX033.

Related Conditions:
Metabolic Disease, Metabolic Disorders, Endocrinology Disorders, Hyperinsulinism, Hypoglycemia, Clinical Research, Clinical Trials, Rare Disorder Natural History Studies and Clinical Trials, Rare Genetic Disorders, Diabetes and other Metabolic Diseases, Rare Disease, Genetic Disease, Genetic Disorders
This study is actively recruiting.