CHOP/Penn Perinatal Infectious Diseases Research Highlights

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The CHOP/Penn Perinatal Infectious Diseases research group is collaboration of CHOP and Penn clinical researchers studying perinatal infectious diseases, including infection transmission and prevention, antibiotic stewardship and resistance, seroepidemiology, and the developing microbiome. Learn about the CPPID’s ongoing research efforts:

  • The purpose of this study is to determine the proportion of pregnant American women who have naturally occurring, serotype-specific antibody to Group B Streptococcus.
  • PI: Karen Puopolo, MD, PhD
  • Collaborators: Duke University, Emory University, University of Texas Houston
  • Funding: Centers for Disease Control and Prevention
  • The purpose of this pharmacoepidemiology study is to identify meaningful metrics of neonatal antibiotic use, in order to allow hospitals and stakeholders to pinpoint antibiotic utilization practices that should be emulated or avoided, and ultimately improve the safety and quality of neonatal care.
  • PI: Dustin Flannery, DO, MSCE
  • Funding: Agency for Healthcare Research and Quality
  • The purpose of this study is to determine the impact of cesarean section delivery on the rate of weight gain in the first five years after birth.
  • PI: Karen Puopolo, MD, PhD
  • Collaborators: Kaiser Southern California
  • Funding: Centers for Disease Control and Prevention
  • One-third of American babies are exposed to antibiotics around the time of birth. The goal of this study is to assess the relationship of these antibiotic exposures to the development of early childhood allergy and infections. The results of this study may alter the perceived safety of prophylactic antibiotics and profoundly affect newborn clinical practice.
  • PI: Sagori Mukhopadhyay, MD, MMSc
  • Funding: National Institute of Child Health and Human Development
  • The objective of this study is to determine the epidemiology of bacterial antibiotic resistance among a large sample of infants admitted to NICUs across the US.
  • PI: Dustin Flannery, DO, MSCE
  • Collaborators: Duke University, University of Michigan
  • Funding: Children’s Hospital of Philadelphia
  • The objective of this study is to assemble and follow longitudinally a large, diverse birth cohort to determine the relationship between (1) antibiotic exposure and gut microbiome development; (2) antibiotic exposure and weight gain/adiposity; (3) and microbiome development and weight gain/adiposity.
  • PI: Jeffrey Gerber, MD, PhD
  • Collaborators: University of Minnesota
  • Funding: National Institute of Allergy and Infectious Disease
  • This study will utilize a national perinatal COVID-19 registry to describe maternal and newborn demographic and clinical characteristics associated with maternal COVID-19 at the time of birth, and the incidence of perinatal and postnatal transmission of SARS-CoV-2 from mothers to their newborns
  • PI: Karen Puopolo, MD, PhD
  • Collaborators: University of Florida, American Academy of Pediatrics
  • Funding: Centers for Disease Control and Prevention
  • This study will assess overall seroprevalence among the women giving birth in two maternity centers in Philadelphia and specifically will estimate the placental transfer of antibody at different stages of maternal infection and at different gestational ages.
  • PI: Karen Puopolo, MD, PhD
  • Collaborators: University of Pennsylvania Department of Microbiology and Department of Obstetrics and Gynecology
  • Funding: Children's Hospital of Philadelphia