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CHOP/Penn Perinatal Infectious Diseases Research Highlights

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The CHOP/Penn Perinatal Infectious Diseases research group is collaboration of CHOP and Penn clinical researchers studying perinatal infectious diseases, including infection transmission and prevention, antibiotic stewardship and resistance, seroepidemiology, and the developing microbiome. Learn about the CPPID’s ongoing research efforts:

  • The purpose of this study is to determine the proportion of pregnant American women who have naturally occurring, serotype-specific antibody to Group B Streptococcus.
  • PI: Karen Puopolo, MD, PhD
  • Collaborators: Duke University, Emory University, University of Texas Houston
  • Funding: Centers for Disease Control and Prevention
  • The purpose of this pharmacoepidemiology study is to identify meaningful metrics of neonatal antibiotic use, in order to allow hospitals and stakeholders to pinpoint antibiotic utilization practices that should be emulated or avoided, and ultimately improve the safety and quality of neonatal care.
  • PI: Dustin Flannery, DO, MSCE
  • Funding: Agency for Healthcare Research and Quality
  • This is a multicenter implementation study to optimize vancomycin use in preterm infants. The study will provide a road map for the broader implementation of antibiotic stewardship measures across NICUs in the United States and provide insights into the factors influencing antibiotic prescribing behavior in the NICU.
  • PI: Sagori Mukhopadhyay
  • The goal of this proposal is to combine subtypes of preterm delivery with intrapartum and early-life factors to identify therapeutically relevant phenotypes that will predict risk of late-onset sepsis and weight gain trajectories.
  • PI: Sagori Mukhopadhyay
  • Funding: NICHD (NIH)
  • The purpose of the study is to determine the genotypic and phenotypic characterization of strains from cases of neonatal E. coli infection. The study aims to: Phylogroup and sequence type, Clonal, virulence-associated and antibiotic resistance-associated traits/genes, Relatedness to other E. coli sequences in the public databases and the PSU reference center, and Differences between early and late infection, blood vs other, relationships between isolates (heterogeneity).
  • PI: Dustin Flannery
  • For collaboration or site participation please contact PI: Dustin Flannery at [email protected]  
  • This is a de-identified serosurveillance cohort of pregnant women and newborns which is harnessed to conduct retrospective and prospective seroepidemiology research. The registry contains serum samples and limited clinical data from maternal-neonatal dyads delivering at two large Penn perinatal centers, with over 6 years of births represented to date.
  • PI: Sarah Coggins
  • For collaboration, please contact PI: Sarah Coggins at [email protected]
  • This is a prospective cohort study of very low birth weight infants from their admission in PAH ICN to 2 years corrected gestational age. We collect weekly fecal stool samples and discarded serum sample to understand the changes in the infant microbiome and immune markers with important clinical outcomes.
  • PI: Sagori Mukhopadhyay
  • Funding: ITMAT Upenn (completed), PenNSAM, CHOP Academic enrichment funds.
  • For collaboration, please contact [email protected]