The Center for Human Phenomic Science was formed with the receipt of the Clinical and Translational Science Award (CTSA), an NIH Roadmap initiative. The CHPS merged the General Clinical Research Centers (GCRCs) at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania Health System (UPHS), and introduced new programs and services. The CHPS has child and adult specific facilities at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania Health System (UPHS), respectively, as well as joint components.

It is the policy of the Center to charge for services provided to investigators for the purpose of supporting the program and expanding the current services available. It is very important for investigators to contact the CHPS Administrative Director, John Krall at krallj@email.chop.edu or 267-425-1790, prior to submitting external grant applications.


The goal of the CHPS is to provide the resources, environment, operations, and training to support and promote high-quality clinical and translational research by qualified investigators. The CHPS supports the research of more than 300 different principal investigators from Penn and CHOP engaged in over 400 research protocols. All protocols are approved by the CHPS Resource Committee.

Research Nursing Core

The Center for Human Phenomic Science (CHPS) is staffed by experienced, qualified research nurses for inpatient and outpatient activities. The nurses, medical assistants and lab techs support a wide variety of research protocols. CHOP CHPS Nursing support is available at two outpatient locations at the Wood Building and 3550 Market Street, the CHPS Inpatient Unit on 5 West, and other CHOP inpatient units as necessary. All studies require IRB and CHPS approval before CHPS services can be provided.

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Nutrition Core

The Nutrition Core has two components.

  • The Nutrition Assessment Unit is a state-of-the-art facility for the assessment of growth and body dimensions, body composition (the amount of muscle, fat and bone in the body), energy expenditure, bone density, and muscle strength. The Core provides consultation and technical expertise for these assessments. The Unit has two locations and four experienced research technicians for performing nutrition assessments.
  • The Dietary Assessment Unit is staffed by experienced registered dietitians and provides a broad range of nutrition-related research services to investigators.

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Sleep Core

The Sleep Core provides services in support of clinical sleep research. It is based at two sites: the CHOP Sleep Laboratory (pediatric), convenient to the CHPS Outpatient Facility on the 1st Floor of Main Hospital and the University of Pennsylvania's Sleep Laboratory (adult), located on the 11th Floor of the Gates Building which is part of the medical complex of the Hospital of the University of Pennsylvania. The Sleep Core contains a total of six designated research beds, dedicated staff, and state-of-the-art equipment that provides support for a variety of sleep-related research initiatives.

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Cardiovascular Core

The CHPS Cardiovascular Core provides cardiac testing services at CHOP for pediatric subjects. The Cardiovascular Core has four sub-cores:

Behavioral Neuroscience Core

The Behavioral Neuroscience Core provides consultation and assistance to investigators regarding psychological, neuropsychological, and psychiatric components of research studies involving pediatric subjects. The Core is highly experienced in implementing multisite protocols.

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Study Design and Biostatistics

Study Design and Biostatistics provides research study planning and analytic services, such as study design, sample size estimation, analysis planning, as well as production of statistical reports and graphical displays.

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Informatics Core

The Informatics Core provides assistance with database development and CRF form development and other computing needs.

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Ophthalmology Core

CHPS offers ophthalmological testing services for children. The Ophthalmology Core was established to provide clinical and translational research services in ophthalmology for the assessment of visual function and structure.

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