CMEM News & Announcements

Douglas C. Wallace, PhD, investigates the role of adaptive immunity in the etiology of Alzheimer’s disease (AD) and AD-related dementias.

The FDA approved an oral drug, based on foundational research conducted at CHOP, to treat a rare, severe bone disease. More In The News.

While mitochondrial function recovered in the lungs, function did not recover in the heart and other organs, leading to long-term damage and a possible explanation for detrimental effects of “long COVID.”

With a grant from the Gates Foundation, CHOP researchers are working to determine the importance of mitochondria DNA variation in COVID-19 severity.

Featured Diversity Fellow Arnold Olali, PhD, is focused on understanding how mitochondria affect overall health.

A U.S. Department of Defense grant will support CHOP researchers in their study of noninvasive methods to diagnose mitochondrial diseases.

Learn about novel findings from our Children’s Hospital of Philadelphia researchers.

New study shows how nicotimamide riboside, part of the vitamin B3 family, could mitigate myopathy caused by a genetic variant.

Read about the latest discoveries and awards at Children’s Hospital of Philadelphia Research Institute.

The mitochondrial genetic status of patients should be considered when recommending exercise as therapy.

The Center for Mitochondrial and Epigenomic Medicine will be awarding two research grants of $25,000 each for the period of January 1, 2022

Findings support lysosomal acidification strategies for pediatric neurodegenerative disorders with impaired mitochondrial quality control.

CHOP and Penn researchers find connection between mitochondrial function and mental illness in patients with a rare genetic disorder.

The results of the study may eventually lead to targeted prevention and treatment strategies for patients with the condition.

Discover new findings about COVID-19 testing before surgery, the link between mitochondria and autism, and how neighborhoods affect sleep.

Autism spectrum disorder may be caused by defects in the mitochondria of brain cells, according to new research published online in PNAS.

Request for applications for four $25,000 grants: Center for Mitochondrial and Epigenomic Research (CMEM)

Study is part of major NASA package of 29 papers assessing the impact of spaceflight on human health.

Researchers at CHOP collaborated with NASA and other institutions to determine possible mechanisms behind the health effects of spaceflight.

This week, researchers elucidate mechanisms of mitochondrial DNA mutations, identify a new neurodevelopmental syndrome, and more.

CHOP researcher: Massively parallel single-nucleus sequencing offers key tool in cardiac biology and heart disease

From novel findings about the role of mtDNA in heart disease to news about the 2nd Eagles Autism Challenge, we've got the latest headlines.

CHOP Researchers Show Proof-of-Principle for Modifier Effects and Disease Progression in Heart Disease

Two-hundred attendees gathered for the first Lifespan Brain Institute Symposium to dig deep into the neurobiological development of mental illness.

From studying smartphone use to sports-related injuries, don't miss this week's roundup of news updates from CHOP researchers.

We rounded up the top 10 stories that captivated our readers' attention in 2017.

We rounded up the top 10 stories that captivated our readers' attention in 2017.

"There is a great sense of community and interconnectedness among the folks who are here," said an attendee of the 10th Annual Friedreich's Ataxia Symposium.

Douglas C. Wallace, PhD, Director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia, was awarded the 2017 Dr. Paul Janssen Award for Biomedical Research on Sept. 13.

The human genome provides a precise, biological blueprint of life. To implement this blueprint correctly, the genome must be read with great precision, but it's impossible for this process to be completely error-free. Mistakes during transcription - random errors in how DNA…

September marks National Childhood Cancer Awareness Month, and this year at Children's Hospital of Philadelphia, we kick-started the commemorative period on the heels of exciting news about breakthroughs in pediatric cancer immunotherapy research.

CHOP Scientist: Ancient Mitochondrial DNA Genetic Patterns May Play Role in this Neurodevelopmental Condition

Differences in mitochondrial function are a major factor in understanding the origins of autism spectrum disorders (ASD), according to a new study led by Douglas Wallace, PhD, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of…

Energy continues to build for the role of the mitochondrion in health and disease, a field pioneered by Douglas Wallace, PhD, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia.

A march, a medal, and a media blitz: In this week's research news, Children's Hospital of Philadelphia investigators made their mark in the history of progressive science in big, bold ways.

Although October is just ending, we're already looking ahead to the New Year in this week's installment of In the News.

Buckle your seatbelts because this has been a busy week for research news at Children's Hospital of Philadelphia. (It was also Teen Driver Safety Week, a topic we touched on with one of our blog posts earlier this week and in last week's In the News post.) Cancer…

Yippee! Hooray! Woo-hoo! We'd like to take a few moments to celebrate the recent accolades given to scientists and physician researchers at The Children's Hospital of Philadelphia Research Institute who are featured in the latest issue of Bench to Bedside, our monthly…

Welcome back to another weekly roundup of research news from The Children’s Hospital of Philadelphia! As we head into Memorial Day weekend in the U.S. and the informal start to summer, let’s begin with news this week that resonates with some of the things we love about summer.

What happens when you combine curiosity, families, and science and technology? You’d know the answer to that question and lots more if you attended the Philadelphia Science Festival, a massive science carnival held over nine days featuring hands-on experiments and demonstrations…

New research suggests that the tiny structures inside our cells that generate energy, called mitochondria, may play a role in our mind-body interactions and how we respond to stressful environments.

Mitochondria are not only the power plants of our cells; these tiny structures also play a central role in our physiology. Furthermore, by enabling flexible physiological responses to new environments, mitochondria have helped humans and other mammals to adapt and evolve…

Certain defects in the way the mitochondria work may lead to diabetes, and the ways our bodies adapt to high blood sugars share many features with the ways our bodies respond to mitochondrial disease.

Recent work by a mitochondrial medicine pioneer from The Children’s Hospital of Philadelphia details how subtle changes in mitochondrial function may cause a broad range of common metabolic and degenerative diseases.

What causes disease? Why do we get sick? Douglas Wallace's answer could spark a revolution in medical thinking. For thousands of years, practitioners of Eastern medicine have linked human health to the concept of energy, or "qi" - its presence, absence and flow…

A team led by CHOP's Marni J. Falk, MD, has expanded next-generation gene tools designed to sequence nuclear DNA to analyze a separate source of DNA - that found within mitochondria. Mitochondria are key suppliers of the energy needed for the multiple functions of our cells.