The Bassiri Lab has long been interested in the interplay between non-conventional lymphocytes (e.g. natural killer T cells or natural killer cells) and their contribution to antitumor immunity. Recently, the lab has focused its studies on elucidating the immunometabolic features of invariant natural killer T cells that may allow them to be used as a platform for cellular immunotherapy of high-risk pediatric solid tumors such as neuroblastoma.
- Directing natural killer T cell and natural killer cell anti-tumor responses
- Natural killer T cell immunometabolism and function
- Altering the neuroblastoma immune environment to control tumor growth