The Epilepsy Research Laboratory

Research Publications

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• Wu HY, Hsu FC, Gleichman AJ, Baconguis I, Coulter DA, Lynch DR. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.  J. Biol Chem 282(28):20075-20087, 2007.
  
• Ang CW, Carlson GC, and Coulter DA.  Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy.  J. Neurosci, 6(46):11850-11856, 2006.
• Lazarewicz MT, Ang CW, Carlson GC, Coulter DA, Finkel LH. Analysis of NMDA-dependent voltage bistability in think dendritic compartments. Neucom 69:1025-29, 2006.
• Liang SL, Carlson GC, and Coulter DA. Dynamic Regulation of Synaptic GABA Release by the Glutamate-Glutamine Cycle in Hippocampal Area CA1. J. Neurosci 26(33):8537-48, 2006.
• Dong YN, Wu HY, Hsu F, Coulter DA, and Lynch DR. Developmental and Cell Selective Variations in N-Methyl-D-Aspartate Receptor Degradation by Calpain. J Neurochem 99(1):206-17, 2006.
• Zhang L,Pathak HR, Coulter DA, Freed MA, and Vardi N. Shift of Intracellular Chloride Concentration in Ganglion and Amacrine Cells of Developing Mouse Retina. J. Neurophysiol 95(4):2404-2416, 2006.
• Ang CW, Carlson GC, Coulter DA. Hippocampal CA1 Circuitry Dynamically Gates Direct Cortical Inputs Preferentially at Theta Frequencies. J Neurosci 25(42) 9567-80, 2005.
• Porter BE, Zhang G, Celix J, Hsu FC, Raol YH, Telfeian A, Gallagher PR, Coulter DA, Brooks-Kayal, AR. Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiology of Disease 18:484-491, 2005.
• Zhang G, Raol, YH, Hsu FC, Coulter DA, Brooks-Kayal, AR. Effects of Status Epilepticus on Hippocampal GABAA Receptors are Age-Dependent. Neuroscience 125:299-303, 2004.
• Nitzan YB, Sekler I, Frederickson CJ, Coulter DA, Balaji RV, LIang, S-L, Margulis A, Hershfinkel M, Silverman WF. Clioquinol effects on tissue chelatable zinc in mice. J Mol Med 81:637-644, 2003.
• Hsu FC, Zhang G, Raol Y, Valentino RJ, Coulter DA, Brooks-Kayal A. Repeated Neonatal Handling with Maternal Separation Permanently Alters Hippocampal GABAA Receptors and Behavioral Stress Responses. PNAS. 100(21):12213-12218, 2003.
• Rafiq A, Gong QZ, Lyeth BG, DeLorenzo RJ, Coulter DA. Induction of Prolonged Electrographic Seizures In Vitro has a Defined Threshold and is All or None: Implications for Diagnosis of Status Epilepticus Epilepsia 44(8):1034-1041, 2003.
• Burton DY, Song S, Fishbein I, Hazelwood S, Li Q, DeFelice S, Connolly JM, Perlstein I, Coulter DA, and Levy RJ. The Incorporation of an Ion Channel Gene Mutation Associated with the Long QT Syndrome (Q9E-hMiRPI) in a Plasmid Vector for Site-Specific Arrhythmia Gene Therapy: In Vitro and In Vivo feasibility studies. Human Gene Therapy 14:907-922, 2003.
• Cohen AS, Lin DD, Quirk GL, Coulter DA. Dentate Granule Cell GABA Receptors in Epileptic Hippocampus: Enhanced Synaptic Efficacy and Altered Pharmacology. European Journal of Neuroscience. 17:1607-1616, 2003.
• Coulter, DA. H-channels as a Therapeutic Target in Epilepsy. Commentary on Poolos NP, Migliore M, Johnston D, Nat Neurosci 5(8):767-774, 2002 and Surges R, Freiman TM, Feuerstein TJ. Epilepsia 44(2):150-156, 2003. Epilepsy Currents, September/October 2003, Volume 3, Number 5.
• Coulter, DA. Sprouted Mossy Fibers Form Primarily Excitatory Connections. Commentary on Buckmaster PS, Zhang GF, Yamawaki R, J Neurosci 22:6650-6658. Epilepsy Currents, November/December 2002, Volume 2, Number 6.
• Sepkuty JP, Cohen AS, Eccles C, Rafiq A, Behar K, Ganel R, Coulter DA and Rothstein JD. A Neuronal Glutamate Transporter Contributes to Neurotransmitter GABA Synthesis and Epilepsy. J Neurosci. 22(15):6372-6379, 2002.
• Coulter DA, McIntyre DC, Loscher W. Animal Models of Limbic Epilepsies: What can they tell us? Brain Pathology 12:240-256, 2002.
• Itoh T, Beesley J, Itoh A, Kavanaugh B, Cohen AS, Coulter DA, Grinspan JB, Pleasure D. AMPA Glutamate Receptor-Mediated Calcium Signaling is Transiently Enhanced During Development of Oligodendrocytes, J Neurochem 81:390-402, 2002.
• Gibbs III, JW, Zhang, Y.-F, Ahmed, H.S., and Coulter DA. Anticonvulsant Actions of Lamotrigine on Spontaneous Thalamocortical Rhythms. Epilepsia 43(4):342-349, 2002.
• Crino PB, Jin H, Shumate MD, Robinson MB, Coulter DA, Brooks-Kayal, AR. Increased Expression of the Neuronal Glutamate Transporter (EAAT3/EAAC1) in Hippocampal and Neocortical Epilepsy. Epilepsia 43(3):211-218, 2002.
• Guttmann RP, Baker DL, Seifert KM, Cohen AS, Coulter DA, and Lynch DR. Specific Proteolysis of the NR2 Subunit of Multiple Sites by Calpain. J Neurochem 78:1083-1093, 2001.
• Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Kelly ME, and Coulter DA. GABAA Receptor Subunit Expression Predicts Functional Changes in Dentate Granule Cells During Postnatal Development. J Neurochem 77:1266-1278, 2001.
• Lin DD, Cohen AS, Coulter DA. Zinc-Induced Augmentation of Excitatory Synaptic Currents and Glutamate Receptor Responses in Hippocampal CA3 Neurons. J Neurophysiol 85:1185-96, 2001.
• Coulter, D.A. Epilepsy-associated Plasticity in Y-aminobutyric Acid Receptor Expression, Function, and Inhibitory Synaptic Properties. International Review of Neurobiology 45:237-252, 2001.
• Cohen AS, Lin DD, Coulter DA. Protracted Postnatal Development of Inhibitory Synaptic Transmission in Rat Hippocampal Area CA1 Neurons. J Neurophysiol 84:2465-76, 2000.
• Coulter, D.A. Mossy Fiber Zinc and Temporal Lobe Epilepsy: Pathological Association with Altered Epileptic GABAA Receptors in Dentate Granule Cells. Epilepsia 41 Suppl 6:S96-9, 2000.
• Coulter DA. Cellular Pathophysiological Mechanisms in Status Epilepticus. Advances in Neurology In Press, 2000.
• Gibbs JW III, Zhang YF, Shumate M, Coulter DA. Regionally Selective Blockade of GABAergic Inhibition by Zinc in the Thalamocortical System: Functional Significance. J Neurophysiol 83:1510-21, 2000.
• Coulter D.A. and DeLorenzo R. J. Basic Mechanisms of Status Epilepticus. Advances in Neurology 79:725-33, 1999.
• Brooks-Kayal AR, Shumate MD, Jin H, Lin DD, Rikhter TY, Holloway K, Coulter DA. Human Neuronal-Aminobutyric AcidA Receptors: Coordinated Subunit mRNA Expression and Functional Correlates in Individual Dentate Granule Cells. J Neurosci 19:8312-8318, 1999.
• Coulter DA. Chronic Epileptogenic Cellular Alterations in the Limbic System Following Status Epilepticus. Epilepsia 40(S1):S23-S33, 1999.
• Gibbs III JW, Sombati S, DeLorenzo RJ, Coulter DA. Cellular Actions of Topiramate: Blockade of Kainate-Evoked Inward Currents in Cultured Hippocampal Neurons. Epilepsia 41 (Supplement 1): S10-S16, 2000.
• DeLorenzo RJ, Sombati S, Coulter DA. Effects of Topiramate on Sustained Repetitive Firing and Spontaneous Recurrent Seizure Discharges in Cultured Hippocampal Neurons. Epilepsia 41 (Supplement 1): S40-S44, 2000.
• Shumate MD, Lin DD, Gibbs III JW, Holloway KL, Coulter DA. GABAA Receptor Function in Epileptic Human Dentate Granule Cells: Comparison to Epileptic and Control Rat. Epilepsy Res 32(1-2):114-28, 1998.
• Brooks-Kayal AR, Shumate MD, Hong Y, Rikhter TY, Coulter DA. Selective Changes in Single Cell GABAA Receptor Subunit Expression Correlate with Altered Function in Epileptic Hippocampus. Nat Med 4(10):1166-72, 1998.
• Gibbs JW III, Morton L, Amaker B, Ward JD, Holloway KL, Coulter DA. Physiological Analysis of Rasmussen's Encephalitis: Patch Clamp Recordings of Altered Inhibitory Neurotransmitter Function in Resected Frontal Cortical Tissue. Epilepsy Res 31(1):13-27, 1998.
• Coulter DA. Antiepileptic Drug Cellular Mechanisms of Action: Where Does Lamotrigine Fit In? J Child Neurol 12(Suppl. 1):S2-S9, 1997.
• Kao CQ, Coulter DA. Physiology and Pharmacology of Corticothalamic Stimulation-Evoked Responses in Rat Somatosensory Thalamic Neurons In Vitro. J Neurophysiol 77(5):2661-76, 1997.
• Gibbs III JW, Shumate MD, Coulter DA. Differential Epilepsy-Associated Alterations in Postsynaptic GABAA Receptor Function in Dentate Granule and CA1 Neurons. J Neurophysiol 77(4):1924-38, 1997.
• Gibbs JW III, Sombati S, DeLorenzo RJ, Coulter DA. Physiological and Pharmacological Alterations in Postsynaptic GABAA Receptor Function in a Hippocampal Culture Model of Chronic Spontaneous Seizures. J Neurophysiol 77(4):2139-52, 1997.
• Gibbs III JW, Berkow GB, Coulter DA. GABAA Receptor Function in Developing Rat Thalamic Reticular Neurons: Whole-Cell Recordings of GABA-Mediated Currents and Modulation by Clonazepam. J Neurophysiol 76(4):2568-79, 1996.
• Rice A, Rafiq A, Shapiro SM, Jakoi EM, Coulter DA, DeLorenzo RJ. Long-lasting Reduction in inhibitory Function and GABAA mRNA Subunit Expression in a Model of Temporal Lobe Epilepsy. Proc Natl Acad Sci USA 93:9665-69, 1996.
• Vick RS, Rafiq A, Coulter DA, Jakoi E, DeLorenzo RJ. GABAA 2 mRNA Levels are Decreased Following Epileptogenesis in Hippocampal-Entorhinal Cortical Slices. Brain Res 721:111-19, 1996.
• Coulter DA, Rafiq A, Shumate M, Gong QZ, DeLorenzo RJ, Lyeth BG. Brain injury-induced enhanced limbic epileptogenesis: Physiological and Anatomical Parallels to an Animal Model of Temporal Lobe Epilepsy. Epilepsy Res 26:81-91, 1996.
• Gibbs III JW, Zhang YF, Kao CQ, Holloway KL, Oh KS, Coulter DA. Characterization of GABAA Receptor Function in Human Temporal Cortical Neurons. J Neurophysiol 75(4):1458-71, 1996.
• Zhang YF, Coulter DA. Anticonvulsant Drug Effects on Spontaneous Thalamocortical Rhythms In Vitro: Carbamazepine, Phenobarbital, and Phenytoin. Epilepsy Res 23(1):55-70, 1996.
• Zhang YF, Gibbs III, JW, Coulter DA. Anticonvulsant Drug Effects on Spontaneous Thalamocortical Rhythms In Vitro: Valproic Acid, Methyl-phenyl Succinimide, and Clonazepam. Epilepsy Res 23(1):37-53, 1996.
• Zhang YF, Gibbs III JW, Coulter DA. Anticonvulsant Drug Effects on Spontaneous Thalamocortical Rhythms In Vitro: Ethosuximide, Trimethadione, and Dimethadione. Epilepsy Res 23(1):15-36, 1996.
• Kapur, J., and Coulter, D.A. Experimental Status Epilepticus Alters Aminobutyric Acid Type A Receptor Function in CA1 Pyramidal Neurons. Ann Neurol 38:893-900, 1995.
• Rafiq A, Zhang YF, DeLorenzo RJ, Coulter DA. Long Duration Self-Sustained Epileptiform Activity in the Hippocampal-Parahippocampal Slice: A Model of Status Epilepticus. J Neurophysiol 74:2028-42, 1995.
• Oh KS, Lee CJ, Gibbs JW, Coulter DA. Postnatal development of GABAA Receptor Function in Somatosensory Thalamus and Cortex: Whole-Cell Voltage-Clamp Recordings in Acutely Isolated Rat Neurons. J Neurosci 15:1341-51, 1995.
• Coulter DA, Lee CJ. Thalamocortical Rhythm Generation In Vitro: Extra-and Intracellular Recordings in Mouse Thalamocortical Slices Perfused with Low-Mg2+ Medium. Brain Res 631:137-42, 1993.
• Rafiq A, DeLorenzo RJ, Coulter DA. Generation and Propagation of Epileptiform Discharges in a Combined Entorhinal Cortex/hippocampal Slice. J Neurophysiol 70:1962-74, 1993.
• Coulter DA, Sombati S, DeLorenzo RJ. Electrophysiology of Glutamate Neurotoxicity In Vitro: Induction of a Calcium-Dependent Extended Neuronal Depolarization. J Neurophysiol 68:362-73,1992.
• Sombati S, Coulter DA, DeLorenzo RJ. Neurotoxic Activation of Glutamate Receptors Induces an Extended Neuronal Depolarization in Cultured Hippocampal Neurons. Brain Res 566:316-19,1991.
• Huguenard JR, Coulter DA, Prince DA. A Fast Transient Potassium Current (IA) in Thalamic Relay Neurons: Kinetics of Activation and Inactivation. J Neurophysiol 66:1304-15, 1991.
• Huguenard JR, Coulter DA, Prince DA. Properties of the Low-threshold Calcium Current in Thalamic Relay Neurons: Recovery from Inactivation in Relation to the Control of Repetitive Burst Generation. Exper Brain Res Series 1991;20:39-43.
• Coulter DA, Huguenard JR, Prince DA. Mechanism of Block of Thalamic "T"-type Ca2+ Channels by Petit Mal Anticonvulsants. Exper Brain Res Series 20:201-4, 1991.
• Coulter DA, Huguenard JR, Prince DA. Differential Effects of Petit Mal Anticonvulsants and Convulsants on Thalamic Neurones. II. GABA Current Blockade. Br J Pharmacol 100:807-13,1990.
• Coulter DA, Huguenard JR, Prince DA. Differential Effects of Petit Mal Anticonvulsants and Convulsants on Thalamic Neurones. I. Calcium Current Reduction. Br J Pharmacol 100:800-6,1990.
• Coulter DA, Huguenard JR, Prince DA. Calcium Currents in Rat Thalamic Relay Neurons: Kinetic Properties of Transient, Low-threshold Current. J Physiol (London) 414:587-604, 1989.
• Coulter DA, Huguenard JR, Prince DA. Characterization of Ethosuximide Reduction of Low-threshold Calcium Current in Thalamic Neurons. Ann Neurol 25:582-93, 1989.
• Coulter DA, LoTurco JJ, Kubota M, Disterhoft JF, Moore JW, Alkon DL. Classical Conditioning Reduces Amplitude and Duration of Calcium-Dependent Afterhyperpolarization in Rabbit Hippocampal Pyramidal Cells. J Neurophysiol 61(5):971-81, 1989.
• Coulter DA, Huguenard JR, Prince DA. Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett 98:74-8,1989.
• Disterhoft JF, Golden DT, Read HR, Coulter DA, Alkon DL. AHP reductions in rabbit hippocampal neurons during conditioning correlate with acquisition of the learned response. Brain Res 462:118-125,1988.
• Wong BW, Coulter DA, Choi DW, Prince DA. Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize NMDA in brain slices. Neurosci Lett 85:261-6, 1988.
• LoTurco JJ, Coulter DA, Alkon DL. Enhanced summation of synaptic potentials: a correlate of associative memory in rabbit CA1 pyramidal neurons. Proc Natl Acad Sci USA 85:1672-6,1988.
• Alkon DL, Kubota M, Neary JT, Naito S, Coulter DA, Rasmussen H. C-Kinase activation prolongs Ca2+-dependent inactivation of K+ currents. Biochem Biophys Res Commun 134:1245-53, 1986.
• Disterhoft JF, Coulter DA, Alkon DL. Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro. Proc Natl Acad Sci USA 83:2733-7, 1986.

EDITORIALS, REVIEWS, CHAPTERS

including participation in committee reports (print or other media):

• 1. Coulter, D.A., Disterhoft, J.F., Bank, B., and Alkon, D.L. Persistent conditioning-specific changes of post-synaptic membrane currents in Hermissenda and hippocampus. In Neuroplasticity, Learning, and Memory. Neurology and Neurobiology, Volume 29. Milgram, N.W., McLeod, C.M., and Petit, T.L., Eds. A. R. Liss, New York, 1987.
• 2. Disterhoft, J.F., Coulter, D.A., and Alkon, D.L. Conditioning specific biophysical alterations in rabbit hippocampus. In: Cellular Mechanisms of Conditioning and Behavioral Plasticity, C.D. Woody, Ed. Plenum, New York, 1988.
• 3. Coulter, D.A., Huguenard, J.R., and Prince, D.A. Cellular actions of petit mal anticonvulsants: Implication of thalamic low-threshold calcium current in generation of spike-wave discharge. Chapter 30 in: Generalized Epilepsy: Neurobiological Approaches. Avoli, M., Gloor, P., Kostopoulos, G., and Naquet, R., Eds. Birkhauser, Boston, 1990.
• 4. Huguenard, J.R., Coulter, D.A., and Prince, D.A. Physiology of thalamic relay neurons: Properties of calcium currents involved in burst firing. Chapter 13 in: Generalized Epilepsy: Neurobiological Approaches. Avoli, M., Gloor, P., Kostopoulos, G., and Naquet, R., Eds. Birkhauser, Boston, 1990.
• 5. Coulter, D.A, and Zhang, Y.-F. Thalamocortical rhythm generation in vitro: Physiological mechanisms, pharmacological control, and relevance to generalized absence epilepsy. In: Idiopathic Generalized Epilepsies: clinical, experimental, and genetic aspects. A. Malafosse, P. Genton, E. Hirsch, C. Marescaux, D. Broglin, and R. Bernasconi, Eds. John Libbey Press, London, 1994.
• 6. Coulter, D.A. Neurophysiological studies in animal models of absence. In: Typical absences and related epileptic syndromes. J.S Duncan and C.P. Panayiotopoulos, Eds. Churchill Livingstone Press, 1995.
• 7. Huguenard, J.R., McCormick, D.A., and Coulter, D.A. Thalamocortical mechanisms. In: Normal and Pathological Physiology of The Cortical Neuron. Gutnick, M.J., and Mody, I., Eds. Oxford University Press, 1995.
• 8. Pellock, J.M., and Coulter, D.A. Tridione. In: Antiepileptic Drugs. Fourth Edition. Levy, R.H., Dreifuss, F.E., Mattson, R.H., Meldrum, B.S., and Penry, J.K., Eds. Raven Press, 1995.
• 9. Coulter, D.A. Thalamocortical anatomy and physiology. Chapter 28 In: Epilepsy. A Comprehensive Textbook. J. Engel, Jr. and T.A. Pedley, Eds. Raven Press, 1997.
• 10. Coulter, D.A., and DeLorenzo, R.J. Basic mechanisms of Status Epilepticus. In: Jasper's Basic Mechanisms of the Epilepsies. Third Edition. Delgado-Escueta, A.V., Wilson, W.A., Olsen, R.W., and Porter, R.J., Eds. Lippincott-Raven Press, Philadelphia, In Press.
• 11. Coulter, D.A. Cellular pathophysiological mechanisms of Status Epilepticus. In: Status Epilepticus: Mechanisms and Management, Wasterlain, C. and Treiman, D.M., Eds. Advances in Neurology, New York, Raven Press.
• 12. Coulter, D.A. GABAA receptor alterations in temporal lobe epilepsy. Chapter 17 In: Childhood Epilepsies and Brain Development, Nehlig, A., Motte, J., Moshe, S.N. and Plouin, P., Eds. John Libbey Press, 1999.
• 13. Coulter, D.A. Epilepsy-associated plasticity in GABA receptor expression, function, and inhibitory synaptic properties. In: Neuroplasticity and Epilepsy, a tribute to Frank Morrell, J. Engel and P.A. Schwartzkroin, Eds. Academic Press, San Diego, In Press, 2000.

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