Pediatric Knowledgebase Receives '2009 Bio-IT World Best Practice Award'


Children’s Hospital’s Pediatric Knowledgebase (PKB) was honored with a 2009 Bio-IT World Best Practice Award on April 29 at the Bio-IT World Conference and Expo.

The PKB was honored with the Judges’ Prize for using technologies that advance drug discovery, biomedical research, and clinical trials to produce patient-specific pharmacotherapeutic guidance. Academic institutions, niche service providers, and pharmaceutical and biotechnology companies made presentations at the Boston conference, which was attended by more than 1,500 participants.

Jeffrey Barrett, Ph.D., Division of Clinical Pharmacology and Therapeutics, led the team that created the PKB — a drug-therapy-focused, comprehensive knowledgebase designed to help physicians individually manage patients’ pharmacotherapy. Designed by the caregiver for the caregiver, the PKB combines data from Epic — the Hospital’s electronic medical record database — with clinical pharmacology data to produce immediate patient-specific drug dashboards.

The dashboards educate physicians on principles of pediatric clinical pharmacology; explore treatments, diagnoses, and drug correlations in conjunction with drug utilization; and provide dosing guidance. The PKB, in essence, has the ability to forecast a patient’s response to a drug.

Currently, physicians use Epic and Sunrise Clinical Manager — the Hospital’s acute clinical care information system — to access patient records, but these interfaces fail to provide dosing histories, indexing, adverse effects, and other pertinent drug-specific information. By synthesizing medical records with scenario-based forecasting of a patient’s response to therapy, the PKB provides drug-specific dosing guidance that, before now, was not readily available for pediatric patients.

“A clinical benefit of this database is it lets physicians know when and how they should intervene,” says Dr. Barrett. “It directly affects children who walk through the door.”

The PKB currently has the following three prototype drug dashboards in clinical evaluation: methotrexate, tacrolimus, and vancomycin. Additionally, an oncology therapy dashboard is in the prototype stage.

The July/August issue of Bio-IT World will feature interviews with and profiles of all award winners.
For more information about the PKB, please visit