Genetic Mechanisms in Pediatric Heart Disease
Program Director: Robert J. Levy, MD
Gene abnormalities have now been demonstrated to be responsible for the pathogenesis of a number of types of congenital heart disease. The Children's Hospital of Philadelphia SCCOR program is based on the following working hypothesis: Basic discoveries concerning genetics and related patterns of gene expression can be applied to a unifying approach for both understanding the complex basis for cardiac dysmorphogenesis as well as providing therapeutic insights for translational directions.