|Study Name||Study Contact||Basic Overview||Criteria|
|Magnetoencephalographic Studies of Lexical Processing and Abstraction in Autism Spectrum Disorders||Principal Investigator (PI)-Tim Roberts
Study Coordinator- Katherine Hines
|• To understand how a child’s brain processes sounds, words and pictures.
• To study brain activity differences between children with ASD and children with typical development.
|• 6-15 years old with a diagnosis of ASD with language impairment.
• 6-15 years old.
• Typical developing.
|autismMatch||Principal Investigator (PI)-Robert Schultz
Study Coordinator- Julianne Fretz
|• To connect families and individuals with ASD with autism research studies at CAR and affiliated centers.||• Children and adults with and without ASD.|
|Determining the Genetics of ASD Through Rapid Ascertainment Within A Regional Community Network||Principal Investigator (PI)-Robert Schultz
|• To obtain and analyze DNA of 1000 individuals with ASD and compare them through to typically developing controls.
• To establish an ASD twin registry as a subset of the sample of 1000, this can be studied in more depth.
|• 4 years old or older.
• Diagnosed with ASD or have a twin sibling with ASD.
• Enrollment in autismMatch, and completion of screening forms
• At least one parent or caregiver English speaking.
|Neuropsychological, Neural, and Genetic Basis of Cognitive Control in ASD||Principal Investigator (PI)-Benjamin Yerys
|• To correlate neuropsychological features, brain imaging features, and genetic risk factors in individuals with ASD and a typically developing (TDC) matched on age, gender-ratio, parental education, and general cognitive ability.||• 6-17 years old.
• English child’s primary language.
• ASD diagnosis.
|Biobehavioral Markers of Anxiety in Autism Spectrum Disorder||Principal Investigator (PI)-John Herrington
|• To understand why some individuals with ASD also have other co-occurring problems such as anxiety. This knowledge may help researchers develop targeted treatments for ASD and co-occurring problems.||• 7-17 years old.
• English is child’s primary language.
• ASD diagnosis.
• ASD + Anxiety diagnosis.
• Anxiety diagnosis.
• Typically developing.
|Genetic Causes for Complex Pediatric Disorders||Principal Investigator (PI)-Hakon Hakonarson
Study Coordinator-Rosetta Chiavacci
|• To study genetic causes for Pediatric Disorders, both common and rare (Crohn’s, diabetes, ADHD and autism).||• Any child and their parents willing to sign consent and have blood samples obtained.|
|Speech Perception and Word Learning in Early Childhood||Principal Investigator (PI)-Dan Swingley
Study Coordinator-Emily Steiner
|• To understand how infants and children acquire language.
• To discover what children know about language above and beyond what children reveal through their own speech.
|• 6 months – 2 years old.
• No known major hearing loss or known significant visual impairment, no significant mental impairments.
|Change and Stability in Risk and Protective Factors||Principal Investigator (PI)- Sara Jaffee
Study Coordinator-Lauren Danzi Brumley
|• To identify change and stability over 12 months in risk and protective factors as a function of exposure to family adversity. • To conduct qualitative interviews with adolescents to learn what resources or individual characterisitics they think protect adolescents from poor school performance and engagin in health risk behaviors.||• English speaking 14-16 year olds with no cognitive disablitlies.|
|Sacrolitis in Juevenile ERA and PsA||Principal Investigator (PI)-Pam Weiss
Study Coordinator-Andy Klink
|• To determine the prevalence of sacroiliitis in children and adolescents with newly diagnosed ERA or PsA.
• To assess the accuracy of physical exam and a history of inflammatory back pain for the detection of sacroiliitis in children and adolescents.
|• Males or females ages 8-18 years old.
• Diagnosed with ERA or PsA within last 6 months.
|Qualitative Assessment of Food Preparation Ability||Principal Investigator (PI)-Chris Feudtner
Study Coordinator-Tim Pian
|• To gain a richer understanding of parental knowledge about food preparation and healthy eating. Household food preparation practices. Challenges parents perceive regarding food and feeding their toddlers in a healthy way. Parental satisfaction with their current food preparation and feeding practices.
• To explore variation in food preparation ability between families from different socioeconomic status levels and diverse cultural backgrounds.
|• 12-24 months old children in Philadelphia.|
|Leber’s Congenital Amaurosis ITMAT||Principal Investigator (PI)-Manzar Ashtari
Study Coordinator-Laura Cyckowski
|• Evaluating cortical visual response in patients undergoing treatment for retinal degenerative disease. -Evaluating control subjects to establish normal visual function longitudinally.||• Healthy males ages 11-14 years old.|
|The SCOUT Study||Principal Investigator (PI)-Theo Zaoutis
Study Coordinator-Lesli Davis
|• To determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through TOC (visit Day 12-14) as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).
• To determine if short-course therapy compared to standard course therapy results in similar numbers of children experiencing a recurrent urinary tract infection (relapse and re-infection).
|• <10 years old.
• No history of prematurity.
|MRI and Cognitive Assessment of Children with CKD||Principal Investigator (PI)-Susan Furth
Study Coordinator-Nina Laney
|• To demonstrate differences in brain imaging between the group of individuals with CKD and age-matched controls.
• To explore the impact of CKD on structural brain integrity as measured by anatomic MRI with quantitative volumetric measurements with a particular focus on prefrontal cortex and frontotemporal regions.
• To characterize the impact of longer duration and increased severity of CKD, HTN and anemia on neurocognitive.
• To develop individual-patient biomarkers by combining structural, ASL and fMRI data in multi-parametric classification.
|• Matched controls to subjects with CKD.|
|Optical Measurement of Cerebral Hemodynamics in Children with Acute Arterial Ischemic Stroke||Principal Investigator (PI)-Daniel Licht
Study Coordinator-Madeline Winters
Phone-484-574-3661 ext. 3164
|• The primary objectives are to determine the variability of CBF in healthy children as HOB position is altered and to determine whether noninvasive monitoring with optical spectroscopy can detect changes in cerebral blood flow as the HOB angle is varied over a range from -5 to +30 degrees in children with ischemic stroke.
• The secondary objective is to determine if the position that maximizes CBF varies over time from stroke onset.
|• Healthy children ages 2-18 years old.|
|Primary Care Drug Therapeutics CER in a Pediatric EHR Network||Principal Investigator (PI)-Alex Fiks
Study Coordinator-Stephanie Mayne
|• To conduct four of proof-of-concept CER studies on psychotropic and asthma medication use and side effects plus an additional full-scale CER study on treatment for pediatric hypertension (HTN).
• To advance the methodology of pediatric pharmacoepidemiological CER using EHR
• To provide a platform for future CER studies in pediatric drug therapeutics and other topic areas.
|• 6-18 years old on psychotropic medications.
• 0-5 years old on asthma medications.
• 3-18 years old on hypertension medication.
|Family Safety Net||Principal Investigator (PI)-Guy Diamond
Study Coordinator-Tita Atte
|• The primary objective of this study is to compare the efficacy of Attachment Based Family Therapy (ABFT) to Family enhanced Non-Directive Supportive Therapy (FE-NST) for reducing suicide ideation at post treatment (16 weeks) and follow up (32 and 52 weeks).
• The secondary objective is to compare the efficacy of ABFT to FE-NST for reducing secondary outcomes including suicide ideation, impression and family conflict at post treatment (16 weeks and follow-up 32 and 52 weeks).
|• 14-24 years old.|
|Youth Suicide Prevention in Primary Care||Principal Investigator (PI)-Guy Diamond
Study Coordinator-Stephanie Ewing
|• To train physicians in suicide risk assessment.
• To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
• To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
|• Any youth presenting with suicidal ideation.|
|Evalutaion of SDM Protal for Pediatric Asthma||Principal Investigator (PI)- Alex Fiks
Study Coordinator–Nathalie Durivage
|• To develop a shared decision making (SDM) electronic medical record (EMR) based portal that engages families of varied backgrounds and clinicians in the care of pediatric chronic illness||• 6-12 years old diagnosis with persistent asthma.|
|A Peer-Based, Social-Media Enabled Intervention to Promote Healthy Growth in Infancy||Principal Investigator (PI)- Alex Fiks
Study Coordinator-Rachel Gruver
|• To develop a peer-based, social media-enabled intervetion to prevent obesity in partnership with the target population of low-income mothers at high risk of having obese chilren, and with pediatricians.
• To pilot test the intervention to establish feasibility, acceptability, and explore its impact on target outbomex, including behaviors associate with healthy growth.
|• Maternal BMI >=25 at <18wks, gestational age >= 20 wks, and maternal age >=18.
• Medicaid/Medical Assistance insurance.
• Plan to receive pediatric primary care at CHOP Care Network site.
• Has a smartphone with texting/data plan and has used phone to obtain photos/videos.
• Able to speak, read & write in English, able to provide informed consent.
• Singleton pregnancy, no severe morbidity, no current dx or significant history of major mental illness.
|Antibiotic Management of Outpatient Pediatric UTI’s||Principal Investigator (PI)-Jeff Gerber
Study Coordinator-Carter Cowden
|• Examine management patterns for UTI’s across CHOP Care Network.||• All children with UTI diagnosis.|
|Cardiometabolic risk and obesity in adolescents with Down syndrome||Principal Investigator (PI)-Sheela Magge
Study Coordinator-Divya Prasad
|• To compare the relationship between BMI-Z score and cardiometabolic risk factors in youth with DS, and in age, sex, race, ethnicity and BMI-Z score matched controls.
• To examine the relationship between obesity, lifestyle (physical activity, nutrition), body image, and quality of life in DS, and to explore barriers to maintaining a healthy weight in children with DS.
• Males and females age 10 to 20 years.
• Diagnosis of DS.
• Parental/guardian permission (informed consent) and if appropriate, child assent. Control Group
• Males and females age 10 to 20 years.
• Parental/guardian permission (informed consent) and if appropriate, child assent.
|Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)||Principal Investigator (PI)- David Sarwer
Study Coordinator-Jacqueline Spitzer
|• To compare the neurobehavioral development of infants/toddlers with and without Craniofacial Microsomia (CFM). • To examine longitudinal relations among facial asymmetry, facial movement and neurobehavioral outcomes among children with CFM. • To assess, among the CFM, the impact of hearing loss on neurobehavioral outcomes both as an isolated variable and the context of other risk factors. • To develop interventions for randomized controlled trials.||• Healthy developing children < 14 months old.|
|Eating Pace Re-Training in Early Childhood Obesity||Principal Investigator (PI)-Bob Berkowitz
Study Coordinator-Samantha Crabbe
|• To retrain children at risk for obesity to reduce their rate of eating during a laboratory test meal, compared with participants in usual care control condition, which receives a brief educational intervention to promote healthy after the final assessment.||• 4-7 yrs old.
• Children have a BMI of 70th-94th percentile for age and sex.
• Have an overweight or obese biological mother with a BMI > 27kg/m2.
|How Do Adolescents Think About The Timing of Sex In Romantic Partnerships||Principal Investigator (PI)- Kenneth Ginsburg
Study Coordinator-Amanda Lerman
|• To evaluate how adolescents think about the timing of the onset of sexual intercourse in new partnerships after lifetime sexual initiation, to elicit their input regarding factors influencing that timing, and to learn the language they use when talking about this idea.||• Eligible adolescents.|
|Adoption of Evidence-Based E-health Child Safety Tools in Pediatric Practice||Principal Investigator (PI)- Linda Fleisher
Study Coordinator-Katie Halkyard
|• Four comprehensive, research-tested web-based tools on teen driving, injury management and recovery, concussion and child safety seats were developed by CIRP and are widely available to the general public on the Center’s website with over 80,000 visits per month. Although these highly interactive tools are well received outside CHOP, there are not being used within the clinical encounter. • This pilot research project will design and implement an implementation study in peditric practices throughout the CHOP network.||• Clinicians.|
|Understanding Novice Teen Drivers’ Attention to the Roadway||Principal Investigator (PI)-Kate McDonald
|• To utilize focus group discussions with teens’ to learn about attitudes and beliefs about keeping their attention on the roadway while driving.||• Teens ages 16-18 years old.
• Hold a Pennsylvania drivers license for 365 days or less.
|Impact of Diet Composition on Energy Balance and Satiety during Infancy||Principal Investigators (PIs)- Julie Mennella and Jillian Trabulsi
Investigator- Virginia Stallings
Study Coordinator- Loma Inamdar
|• To explore energy balance mechanisms (energy intake, energy expenditure, energy loss) and growth during the first year of life in formula fed infants randomized to one of two different types of infant formulas that are currently on the market. Target age of enrollment is when the infant is 7-14 days old. Study requires monthly study visits where the infant will be weighed and measured and mom will answer questionnaires; the next month’s formula is distributed at this time. The study team will continue to follow the infant until he/she is 18 months of age.||Inclusion criteria
Mothers must be older than 18 years of age.
At birth, infants must be:
At the time of enrollment, infants must be:
• Infants who were preterm or have medical conditions that interfere with feeding and/or metabolism or who are lactose intolerant will be excluded from this study.
|Health Outcomes and Healthcare utilization among Food Insecure Children in Primary Care Pracitce||Principal Investigator (PI)-Alex Fiks
Study Coordinator-Deepak Palakshappa
|• To evaluate the rates of food insecurity screening at a large children’s hospital care network. • To evaluate the effect of food insecurity on child growth. • To evaluate the effect of food insecurity on child development and behavioral problems. • To evaluate the effect of food insecurity on laboratory abnormailities. • To evaluate the effects of food insecruity on healthcare utilizatons.||• Retrospective chart review|
|Comparative Effectiveness of Antibiotics for Respiratory Infections (CEAR) Study||Principal Investigator (PI)-Jeff Gerber
Study Coordinator-Neika Vendetti
|• To investigate what parents think about antibiotic therapy, specifically what outcomes they worry about when their child is sick with an acute respiratory tract infection (ARTI)||• Parents of children 3 months-18 years old who present with symptoms consistent with ARTI|
|The Association of Depression and Anxiety with Outpatient Medical Services Utilization in Pediatric Lupus and Mixed Connective Tissue Disorder||Principal Investigator (PI)-Ron Keren
Study Coordinator-Andrea Knight
|• To investigate prevalence of depression and anxiety in CHOP lupus/MCTD cohort, comparing ot healthy child/adolescent popultion.
• To determine association of depression and anxiety with healthcare utilization, quality of life, physical function.
|• Age 8 years old and above.
• No chronic medical condition (Diabetes, IBD, persistent asthma (intermittent allowed), cerebral palsy, sickle cell anemia, cystic fibrosis, cancer, HIV/AIDS, congenital heart disease, any other chronic autoimmune, hematologic, pulmonary, renal, gastrointestinal, neurological or musculoskeletal condition).
• No current use of steroids.
|Study of Female Teens: Understanding Risk to
Promote Breast Health II
(The SOFT II Study)
|Principal Investigator (PI)-Angela Bradbury
Study Coordinator-Dare Henry-Moss
|• To evaluate the relationship between breast cancer risk and psychosocial adjustment, cancer specific stress-response and health and risk behaviors in 11-19 years old girls and how these relationships change over time.
• To explore biopsychosocial factors that might mediate and moderate the relationship between breast cancer risk and psychosocial adjustment, cancer specific stress-response and health behaviors and changes in these outcomes over time.
• To explore mother reported content and method of mother communications to 11-19 year old daughters among BRCA1/2 carriers and the relationshop between the content fo communication and daughter psychosocial adjustment and cancer specific distress and health behaviors.
|• Teenage girls, ages 11-19 years old and their mother.|
|A Pilot Study Evaluating the Transmission and Early Viral Dynamics in Maternal-Fetal Transmission of Hepatitis C Virus||Principal Investigator (PI)-Jessica Wen
Study Coordinator-Lindsay Brown
|• To examine the complexity of the HCV viral genome circulating in infected infants and to quantify the number of individual HCV species leading to productive clinical infection in mother to child HCV transmission using a novel viral sequencing. This will help gain better insights into the barrier an vaccine or prophylaxis medication must overcome to be successful in preventing HCV transmission.||• Infants 6 months and younger born to mothers with Hepatitis C.|
|Keeping Kids Safe and Smoke Free (KISS)||Principal Investigator (PI)-Tyra Bryant-Stephens
Study Coordinator-Canne Dirl
|• To provide partnering physicians and clinic staff with a clinic-level quality improvement intervention to address Second Hand Smoke exposure (SHSe) in the four urban pediatric clinics.||• Children ages 0-11 years old exposed to second hand smoke.|
|Development of Methods for Identifying Child & Parent Health Outcomes||Principal Investigator (PI)-Katherine Bevans
Study Coordinator-Lucia Pattullo
|• To develop and evaluate novel methods for eliciting and prioritizing children’s health outcomes that are comprehensible to both patients and clinicians, measurable, and ready for integration in clinical and comparative effectiveness research.||• Children 12-17 years old.
• Parents of children 8-17 years old.
|Parenting Goals for Outpatient Children with Serious Chronic Conditions||Principal Investigator (PI)-Chris Feudtner
Study Coordinator-Allison Parker
|• To augment our understanding of the TBGP heuristic, assessing whether the attributes that parents value regarding how TBGP vary not only by disease severity but also by where the patient is currently residing, adding to existing samples consisting of hospitalized patients a sample of comparable patients residing at home.||• Parents of children with serious condition/disease.|
|Screening for Intimate Partner Violence in Primary Care||Principal Investigator (PI)-Phil Scribano
Study Coordinator- Tara Wedin
|• To explore the knowledge, attitudes, and beliefs of Primary Care clinicians about their role in identifying adverse childhood experiences (ACEs) and whether or not the Emergency Room should also be screening for specific ACEs including domestic violence.
• To identify perceived barriers toward and preferences for electronic IPV screening in the Primary Care office as the first step toward designing an Emergency Department and Primary Care Office based IPV screen.
|• Staff at Karabots (attending’s, social workers, RNs, NPs).|