Adeno-associated Virus

Crystal structure of the adeno-associated virus

Crystal structure of Adeno-associated Virus (AAV)

Adeno-associated viruses (AAV) are ubiquitous, non-cytopathic, replication incompetent members of the Parvoviridae family. AAV replication requires the presence of a helper virus, and this is usually one of the many serotypes of adenovirus. The epidemiology of AAV infection in humans was extensively studied after its initial description some 40 years ago. Many adults have antibodies reactive against one or more AAV serotypes, a finding which is entirely consistent with early and repeated exposures to AAV and adenoviruses throughout life. Even with this level of exposure, AAV does not cause any disease or other pathologic condition in humans. In recent years, gene transfer vectors based on recombinant AAV (rAAV) have garnered considerable interest as potential agents for a wide assortment of human applications. rAAV vectors are structurally simple and versatile.

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