Toshio
  
Asakura
Email: 
asakurat@email.chop.edu
Address: 
Division of Hematology Room 316G Abramson Building The Children's Hospital of Philadelphia 34th St. & Civic Center Blvd.
2159779779
Affiliations
Expertise
Appointments
Emeritus Professor of Pediatrics at University of Pennsylvania School of Medicine (2013– present)
Assistant Professor of Biochemistry and Biophysics at University of Pennsylvania School of Medicine (1969 – 1974)
Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1973 – 1974)
Research Associate Professor of Pediatrics and Biophysics in Pediatrics at University of Pennsylvania School of Medicine (1974 – 1976)
Professor of Biochemistry and Biophysics at University of Pennsylvania School of Medicine (1976 – 2007)
Professor of Pediatrics at University of Pennsylvania School of Medicine (1976 – 2012)
Education
Ph.D., (Biochemistry), Tokyo University, Japan (1965)
M.D., (Medicine), Kyoto Medical College, Japan (1960)
B.S., (Biology), Kyotofuritsu University, Kyoto, Japan (1956)
Selected Publications
Hayashi, S., Abdulmalik, O., Peranteau, W.H., Ashizuka, S., Campagnoli, C. Chen, Q., Horiuchi, K., Asakura, T., and Flake, A.W. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemlogolobinopathy.. Exp. Hematol.. Vol 31. 2003:176-184.
Iyamu, E.W. and Asakura, T.. Drug Therapy for sickle cell disease.. Exp. Opin. Ther. Patents.. Vol 13. 2003:807-813.
Iyamu, E.W., Adunyah, S.E., Fasold, H., Horiuchi, K. Baliga, S. Ohene-Frempong, K., Turner, E.A., and Asakura, T.. Combined Use of Non-myelosuppressive Nitrosourea Analogues with Hydroxyurea in the Induction of F-cells production in a Human Erythroleukemic cell line.. Exp. Hematol.. Vol 31. 2003:592-600.
Iyamu, E.W., Turner, E.A. and Asakura, T.. The naturally occurring antisickling agent, Nix-0699, prolongs the survival time of transgenic sickle cell mice exposed to acute severe hypoxic conditions.. Brit J Haematol .. Vol 122. 2003:1001-1008.
Abdulmalik, O., Martin, M., Yang, J., Chen, Q., Brugnara, C., Evans, G., Abraham, D. and Asakura, T.. In vitro and in vivo studies on 5-hydroxymethyl-2-furfural (5HMF): A new potent antisickling agent.. American Society of Hematology. 2003.
Iyamu W.E. In vitro effects of NIPRISAN (Nix-0699): a naturally occirring potent antisickling agent.. Brit. J. Haematol.. Vol 118. 2002:337-343.
Zhang, C., Li, X., Lian, L., Q. Chen, L.Q., Vassilev, V., C. Lai, C., Evans G, and Asakura, T. Antisickling effect of MX-1520, A prodrug of vanillin: an in vitro study using rats and transgenic sickle mice.. The 26 th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract. 2002.
sakura, T., Ballas, S., Ohene-Frempong, K., and Lian L.. Existence of two types of reversibly sickled cells in the blood of patients with sickle cell disease: their involvment in the clinical diversity among patients and initiation of vaso-occlusion.. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract. 2002.
Asakura, T., Lian, L., Chen, Q., Iyamu, W.E., Abdulmalik, O., Brugnara, C., and Evans, G.. Five-year summary report of screening screening new therapeutic agents for the treatment of sickle cell disease by the NIH Sickle Cell Disease Reference Laboratory.. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract. 2002.
Abdulmalik, O., Hayashi, S., Chen, Q., Asakura, T., and Flake, A. W.. Evaluation of the efficacy of mixed chimerism in transgenic sickle mice that were treated with in utero hematopoietic stem cell transplantation.. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract. 2002.