Robert
 
O
 
Heuckeroth
M.D. Ph.D.
Email: 
heuckerothr@email.chop.edu
Address: 

The Children's Hospital of Philadelphia - Research Institute
3615 Civic Center Blvd
Abramson Research Center -Suite # 1116i
Philadelphia, PA 19104-4318

215-590-1209
Affiliations

Cell and Molecular Biology
Neuroscience

Expertise

Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. This work involves a combination of molecular biology, genetics, live cell imaging, primary cell culture, epidemiology, physiology, biochemistry, stem cell biology and regenerative medicine. Since the enteric nervous system is derived from actively migrating, proliferating and differentiating neural crest cells, we have broad interests in the complex processes that govern normal and abnormal development with the long term goal of finding new ways to prevent birth defects and to repair damaged organs.

Projects we are currently pursuing include:
1. Defining genetics of Hirschsprung disease and intestinal pseudoobstruction syndrome.
2. Identifying gene-environment interactions that cause human birth defects.
3. Determining mechanisms to control the fate of enteric nervous system stem cells.
4. Developing regenerative medicine approaches to care for children with serious intestinal motility disorders.
5. Establishing translational research programs to improve visualization of the enteric nervous system and bowel wall.
6. Personalized medicine approaches to therapy.

Appointments
Education

B.S. (Chemistry, Summa Cum Laude with high honors in chemistry)
University of Maryland, 1983.
M.D.
Washington University School of Medicine, St. Louis, 1990.
Ph.D. (Biochemistry)
Washington University School of Medicine, St. Louis, 1990.

Selected Publications