Mortimer
  
Poncz
MD
Email: 
poncz@email.chop.edu
Address: 
3615 Civic Center Blvd. Division of Hematology The Children's Hospital of Philadelphia Abramson Research Bdg. Rm. 317
(215) 590-3574
Expertise

CVI Program Unit Administrator:
Thrombosis / Hemostasis

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
Interested in thrombosis and hemostasis, vascular biology, the development of atherosclerosis, and megakaryopoiesis. My studies are mostly on platelets, platelet chemokines, platelet integrins and gene regulation in megakaryopoiesis. I am a pediatric hematologist by training.

Platelet biology in regulating thrombosis using novel approaches for the targeted delivery of coagulation, anti-thrombotic and anti-angiogenic agents.

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Appointments
Professor of Pathology and Laboratory Medicine at University of Pennsylvania School of Medicine (2003 – 2005)
Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1982 – 1989)
Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (1989 – 1994)
Professor of Pediatrics at University of Pennsylvania School of Medicine (1994– present)
Education
M.D., University of Pennsylvania (1976)
B.S., Columbia University (1972)
Selected Publications