Michael
 
D.
 
Hogarty
MD
Email: 
hogartym@email.chop.edu
Address: 
Division of Oncology The Children's Hospital of Philadelphia Colket Translational Research Building, Room 3020 3501 Civic Center Boulevard
2155903931
Affiliations
Expertise

The Hogarty lab works on defining the cancer biopathways that support neuroblastoma tumourigenesis with particular focus on understanding how neuroblasts with MYCN amplification avoid engaging the latent apoptosis programs usually activated with dergulated oncogene activity. We study experimental therapeutics targeting key neuroblast survival pathways.

Appointments
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia (2009– present)
Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (2000 – 2006)
Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (2006 – 2009)
Education
M.D., Columbia University College of Physicians and Surgeons, New York, NY (1990)
B.E.S., Biomedical Engineering, Johns Hopkins University, Baltimore, MD (1986)
Selected Publications
Suganuma Rie, Wang Larry L, Sano Hideki, Naranjo Arlene, London Wendy B, Seeger Robert C, Hogarty Michael D, Gastier-Foster Julie M, Look A Thomas, Park Julie R, Maris John M, Cohn Susan L, Amann Gabriele, Beiske Klaus, Cullinane Catherine J, d'Amore Emanuele S G, Gambini Claudio, Jarzembowski Jason A, Joshi Vijay V, Navarro Samuel, Peuchmaur Michel, Shimada Hiroyuki. Peripheral neuroblastic tumors with genotype-phenotype discordance: A report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.. Pediatric blood & cancer. Vol 60(3) . 2013 Mar:363-70.
Boiani Mariana, Daniel Cristina, Liu Xueyuan, Hogarty Michael D, Marnett Lawrence J. The stress protein BAG3 stabilizes Mcl-1 and promotes survival of cancer cells and resistance to ABT-737.. The Journal of biological chemistry. 2013 Jan.
Pugh Trevor J, Morozova Olena, Attiyeh Edward F, Asgharzadeh Shahab, Wei Jun S, Auclair Daniel, Carter Scott L, Cibulskis Kristian, Hanna Megan, Kiezun Adam, Kim Jaegil, Lawrence Michael S, Lichenstein Lee, McKenna Aaron, Pedamallu Chandra Sekhar, Ramos Alex H, Shefler Erica, Sivachenko Andrey, Sougnez Carrie, Stewart Chip, Ally Adrian, Birol Inanc, Chiu Readman, Corbett Richard D, Hirst Martin, Jackman Shaun D, Kamoh Baljit, Khodabakshi Alireza Hadj, Krzywinski Martin, Lo Allan, Moore Richard A, Mungall Karen L, Qian Jenny, Tam Angela, Thiessen Nina, Zhao Yongjun, Cole Kristina A, Diamond Maura, Diskin Sharon J, Mosse Yael P, Wood Andrew C, Ji Lingyun, Sposto Richard, Badgett Thomas, London Wendy B, Moyer Yvonne, Gastier-Foster Julie M, Smith Malcolm A, Auvil Jaime M Guidry, Gerhard Daniela S, Hogarty Michael D, Jones Steven J M, Lander Eric S, Gabriel Stacey B, Getz Gad, Seeger Robert C, Khan Javed, Marra Marco A, Meyerson Matthew, Maris John M. The genetic landscape of high-risk neuroblastoma.. Nature genetics. 2013 Jan.
Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, Hogarty MD, Simon MC.. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.. Cancer Cell. Vol 22(5) . 2012 Nov:631-44.
Goldsmith KC, Gross M, Pierce S, Luyindula D, Liu X, Vu A, Sliozberg M, Guo R, Zhao H, Reynolds CP, Hogarty MD.. Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma.. Cancer Research. Vol 72(10) . 2012 May:2565-77.
Hogarty Michael D, Maris John M. PI3King on MYCN to improve neuroblastoma therapeutics.. Cancer cell. Vol 21(2) . 2012 Feb:145-7.
Sausen M, Leary RJ, Jones S, Wu J, Reynolds CP, Liu X, Blackford A, Parmigiani G, Diaz Jr LA, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE, Hogarty MD.. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.. Nature Genetics. Vol 45(1) . 2012 Jan:12-7.
Dubois Steven G, Geier Ethan, Batra Vandana, Yee Sook Wah, Neuhaus John, Segal Mark, Martinez Daniel, Pawel Bruce, Yanik Greg, Naranjo Arlene, London Wendy B, Kreissman Susan, Baker David, Attiyeh Edward, Hogarty Michael D, Maris John M, Giacomini Kathleen, Matthay Katherine K. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.. International journal of molecular imaging. Vol 2012. 2012:250834.
De Preter Katleen, Mestdagh Pieter, Vermeulen Joëlle, Zeka Fjoralba, Naranjo Arlene, Bray Isabella, Castel Victoria, Chen Caifu, Drozynska Elzbieta, Eggert Angelika, Hogarty Michael D, Izycka-Swieszewska Ewa, London Wendy B, Noguera Rosa, Piqueras Marta, Bryan Kenneth, Schowe Benjamin, van Sluis Peter, Molenaar Jan J, Schramm Alexander, Schulte Johannes H, Stallings Raymond L, Versteeg Rogier, Laureys Geneviève, Van Roy Nadine, Speleman Frank, Vandesompele Jo. miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples.. Clinical cancer research : an official journal of the American Association for Cancer Research. Vol 17(24) . 2011 Dec:7684-92.
Liu Grant T, Mahoney Nicholas R, Avery Robert A, Menacker Sheryl J, Wilson Martin C, Hogarty Michael D, Maris John M. Pediatric horner syndrome.. Archives of ophthalmology. Vol 129(8) . 2011 Aug:1108-9; author reply 1109.