The Children's Hospital of Philadelphia 34th Street and Civic Center Boulevard 902-E Abramson Research Building

My laboratory is interested in the mechanisms by which esophageal epithelial cells act as innate immune effector cells in the context of GERD and eosinophilic esophagitis.

Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (2005– present)
MD, Medicine, University of Pennsylvania School of Medicine (1995)
BA, Interdisciplinary Studies, Cornell University (1991)
Selected Publications
Muir AB, Lim DM, Benitez AJ, Chandramouleeswaran PM, Lee AJ, Ruchelli ED, Spergel JM, and Wang ML.. Esophageal Epithelial-Mesenchymal Cross-Talk Leads to Features of Epithelial to Mesenchymal Transition In Vitro.. Experimental Cell Research. Vol 319(6) . 2013 Apr:850-9.
Jyonouchi S, Smith C, Saretta F, Abraham V, Ruymann K, Modayur PC, Wang ML, Spergel JM, and Cianferoni A.. Invariant Natural Killer T Cells in Children with Eosinophilic Esophagitis.. Clinical Exp Allergy. 2013 In press.
Siracusa MD, Saenz SA, Tait Wojno ED, Kim BS, Osborne LC, Ziegler C, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, and Artis D. TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity. Vol In press. 2013 In press.
Noti M, Tait-Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman, PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, and Artis D.. TSLP-Elicited Basophil Responses Can Mediate the Pathogenesis of Eosinophilic Esophagitis.. Nature Medicine. Vol 19(8) . 2013:1005-13.
Spergel JM, Brown-Whitehorn TF, Cianferoni A, Shuker M, Wang ML, Verma R, and Liacouras CA. Identification of Causative Foods in Children with Eosinophilic Esophagitis Treated with an Elimination Diet.. Journal of Allergy and Clinical Immunology. Vol 130(2) . 2012 August:461-7.
Lim DM and Wang ML. Toll-Like Receptor 3 Signaling Enables Human Esophageal Epithelial Cells to Sense Endogenous Danger Signals Released by Necrotic Cells.. American Journal of Physiology: Gastrointestinal & Liver Physiology. Vol 301(1) . 2011 July:G91-9.
Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, and Katz JP.. Klf4 Overexpression Activates Epithelial Cytokines and Inflammation-Mediated Esophageal Squamous Cell Cancer in Mice.. Gastroenterology. Vol 139(6) . 2010 December:2124-2134.
Lim DM, Narasimhan S, Michaylira CZ, and Wang ML. TLR3-Mediated NF-kB Signaling in Human Esophageal Epithelial Cells.. American Journal of Physiology: Gastrointestinal and Liver Physiology.. Vol 297. 2009 December:G1172-1180.
Wang ML, Keilbaugh SA, Cash-Mason T, He XC, Li L, and Wu GD.. Immune-Mediated Signaling in Intestinal Goblet Cells via PI3-Kinase and AKT-Dependent Pathways.. American Journal of Physiology: Gastrointestinal and Liver Physiology.. Vol 295(G1122-G1130) . 2008 October.
Barnes SL, Vidrich A, Wang ML, Wu GD, Cominelli F, Rivera-Nieves J, Bamias G, and Cohn SM.. Resistin-Like Molecule Beta (RELMß/FIZZ2) is Highly Expressed in the Ileum of SAMP1/YitFc Mice and is Associated with Initiation of Ileitis.. Journal of Immunology. Vol 179(10) . 2007 November:7012-20.