Mary
 
B.
 
Leonard
MD, MSCE
Email: 
LEONARD@email.chop.edu
Address: 
The Children's Hospital of Philadelphia Division of Pediatric Nephrology 34th Street and Civic Center Boulevard CHOP North, Room 868
(215) 590-0874
Affiliations
Affiliations
Affinity Groups:
Metabolism, Nutrition and Physical Development
Centers and Programs:
Clinical and Translational Research Center (CTRC)
Expertise

Dr. Leonard is an Associate Professor of Pediatrics in the Division of Nephrology at the Children?s Hospital of Philadelphia, and a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania. She has established a multidisciplinary research program in clinical bone disease in children and adults. Her research program is focused on (1) the accurate assessment and diagnosis of osteoporosis in children with chronic disease, (2) the detrimental effects of glucocorticoid therapy, muscle deficits and inflammation on bone development in varied pediatric disorders, (3) the assessment of the unique effects of kidney disease, dialysis and transplantation on skeletal structure in children and adults using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical functioning and cardiovascular disease in adults with chronic kidney disease, and (5) the evaluation of biomechanical interventions as potential anabolic bone therapies in patients with chronic disease.

Dr. Leonard?s research program is supported by multiple NIH investigator-initiated grants, including 3 R01s,and an NIDDK K24 mid-career award. Most recently, she was awarded a grant to conduct a randomized clinical trial of low magnitude mechanical stimuli as an anabolic bone therapy in children with Crohn disease. She also serves as the primary mentor for multiple junior faculty and fellows that are supported by Foundation grants and NIH K awards. Overall, her program has catalyzed interactions among nephrology, nutrition, gastroenterology, endocrinology, rheumatology, radiology, statistics and epidemiology.

Nutrition, Pediatrics, Renal Epidemiology, Osteoporosis

Dr. Leonard investigates: (1) the accurate assessment and diagnosis of osteoporosis in children with chronic disease, (2) the detrimental effects of glucocorticoid therapy, muscle deficits and inflammation on bone development in varied pediatric disorders, (3) the assessment of the unique effects of kidney disease on skeletal structure in children and adults using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical functioning and cardiovascular disease in adults with chronic kidney disease, and (5) the evaluation of biomechanical interventions as potential anabolic bone therapies in patients with chronic disease.

Longitudinal Methods, Multivariate Analysis, Repeated Measures

Appointments
Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (2006 – 2012)
Professor of Pediatrics at University of Pennsylvania School of Medicine (2012– present)
Associate Professor of Epidemiology in Biostatistics and Epidemiology at University of Pennsylvania School of Medicine (2006 – 2012)
Professor of Epidemiology in Biostatistics and Epidemiology at University of Pennsylvania School of Medicine (2012– present)
Assistant Professor of Medicine at University of Pennsylvania School of Medicine (1997 – 2000)
Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1997 – 2006)
Assistant Professor of Biostatistics and Epidemiology at University of Pennsylvania School of Medicine (1998 – 2006)
Education
M.S., Clinical Epidemiology, University of Pennsylvania (1998)
M.D., Stanford University (1989)
B.A., Chemistry, Northwestern University (1984)
Selected Publications
Baker Joshua F, Davis Matthew, Alexander Ruben, Zemel Babette S, Mostoufi-Moab Sogol, Shults Justine, Sulik Michael, Schiferl Daniel J, Leonard Mary B. Associations between body composition and bone density and structure in men and women across the adult age spectrum.. Bone. Vol 53(1) . 2013 Mar:34-41.
Tsampalieros Anne, Kalkwarf Heidi J, Wetzsteon Rachel J, Shults Justine, Zemel Babette S, Foster Bethany J, Foerster Debbie L, Leonard Mary B. Changes in bone structure and the muscle-bone unit in children with chronic kidney disease.. Kidney international. Vol 83(3) . 2013 Mar:495-502.
Tsampalieros Anne, Gupta Pooja, Denburg Michelle R, Shults Justine, Zemel Babette S, Mostoufi-Moab Sogol, Wetzsteon Rachel J, Herskovitz Rita M, Whitehead Krista M, Leonard Mary B. Glucocorticoid effects on changes in bone mineral density and cortical structure in childhood nephrotic syndrome.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Vol 28(3) . 2013 Mar:480-8.
Griffin Lindsay M, Denburg Michelle R, Shults Justine, Furth Susan L, Salusky Isidro B, Hwang Wenke, Leonard Mary B. Nutritional vitamin D use in chronic kidney disease: a survey of pediatric nephrologists.. Pediatric nephrology (Berlin, Germany). Vol 28(2) . 2013 Feb:265-75.
Prosnitz Aaron R, Leonard Mary B, Shults Justine, Zemel Babette S, Hollis Bruce W, Denson Lee A, Baldassano Robert N, Cohen Aaron B, Thayu Meena. Changes in Vitamin D and Parathyroid Hormone Metabolism in Incident Pediatric Crohn's Disease.. Inflammatory bowel diseases. Vol 19(1) . 2013 Jan:45-53.
Denburg M, Tsampalieros AK, de Boer IH, Shults J, Kalkwarf HJ, Zemel BS, Foerster D, Stokes D, Leonard MB. Mineral metabolism and cortical volumetric bone mineral density in childhood CKD. J Clin Endocrinol Metab. Vol 98(5) . 2013:1930-8.
Prosnitz AR, Leonard MB, Shults J, Zemel BS, Hollis BW, Denson LA, Baldassano RN, Cohen AB, Thayu, M.. Changes in Vitamin D and PTH Metabolism in Incident Pediatric Crohn Disease. Inflamm Bowel Dis Journal. Vol 19(1) . 2013:45-53.
Weber David R, Leonard Mary B, Zemel Babette S. Body composition analysis in the pediatric population.. Pediatric endocrinology reviews : PER. Vol 10(1) . 2012 Nov:130-9.
Lo Re Vincent, Volk Jessica, Newcomb Craig W, Yang Yu-Xiao, Freeman Cristin P, Hennessy Sean, Kostman Jay R, Tebas Pablo, Leonard Mary B, Localio A Russell. Risk of hip fracture associated with hepatitis C virus infection and hepatitis C/human immunodeficiency virus coinfection.. Hepatology (Baltimore, Md.). Vol 56(5) . 2012 Nov:1688-98.
Mostoufi-Moab Sogol, Brodsky Jill, Isaacoff Elizabeth J, Tsampalieros Anne, Ginsberg Jill P, Zemel Babette, Shults Justine, Leonard Mary B. Longitudinal assessment of bone density and structure in childhood survivors of acute lymphoblastic leukemia without cranial radiation.. The Journal of clinical endocrinology and metabolism. Vol 97(10) . 2012 Oct:3584-92.