Kazuhiko
  
Adachi
Email: 
adachi@email.chop.edu
Address: 
CHOP 34th & CIVIC CENTER 4399
2159779779
Affiliations
Expertise
Appointments
Research Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1977 – 1980)
Adjunct Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1980 – 1984)
Adjunct Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (1984 – 1984)
Research Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (1985 – 1999)
Research Professor of Pediatrics at University of Pennsylvania School of Medicine (1999 – 2009)
Education
Ph.D., Tokyo Metropolitan University (1973)
M.S., Tokyo Metropolitan University (1969)
B.S., Tokyo Science College (1966)
Selected Publications
Yamaguchi, T., Adachi, K.. Hemoglobin Equilibrium Analysis by the Multigleangle laser light-scattering. Bicchemical Biophysical Research Communication. Vol 290. 2002:1382-1387.
Adachi, K., Zhao, Y and Saul, S.. Assembly of human hemoglobin (Hb) ß-and g-globin chains expressed in a cell-free system with a-globin chains to form Hb A and Hb F.. Journal of Biological Chemistry. Vol 277. 2002:13415-13420.
Ivanova, M. Jasuja, R., Krasnosselkkaia, L., Josephs, R. Wang, Z., Ding, M., Horiuchi, K., Adachi, K., and Ferrone, F. A.. Flexibility and Nucleation in sickle hemoglobin. J. Mol. Biol.. Vol 314. 2001:851-861.
Adachi, K., Yang, Y., Joshi, A., Vasudevan, G., Morris, A and McDonald, M.J.. Consequence of ß16 and ß112 replacements on the kinetics of hemoglobin assembly. Bicchemical Biophysical Research Communication. Vol 289. 2001:75-79.
Adachi, K, Zhao, Y., Yamaguchi T., and Surrey, S.. Assembly of g -with a-globin chains to form human Hb F in vitro and in vivo. Journal of Biological Chemistry,. Vol 275. 2000:12424-12429.
Adachi, K., Yamaguchi T., Yi, Y. Konitzer, P.T., Pang, J., Reddy, K.S., Ivanova, M., Ferrone, F and Surrey, S.. Expression of functional soluble human a-globin chains of Hb in bacteria. Protein Expression and Purification. Vol 20. 2000:37-44.
Yamaguchi, T., Yi, Y., McDonald, M.J. and Adachi, K.. Surface and interface ß-chain residues synergistically affect Hb assembly. Bicchemical Biophysical Research Communication. Vol 270. 2000:683-687.
Kano Y., Akutsu M., Tsunoda S., Mori K., Suzuki K., Adachi KI.. In vitro schedule-dependent interaction between paclitaxel and SN-38 (the active metabolite of irinotecan) in human carcinoma cell lines. Cancer Chemotherapy & Pharmacology. Vol 42(2) . 1998:91-8.
Adachi, K., Yamaguchi, T., Pang, J. and Surrey, S.. Effects of increased anionic charge in the ß-globin chain on assembly of hemoglobin in vitro. Blood. Vol 91. 1998:1438-1445.
Yamaguchi, T., Pang, J., Surrey, S. and Adachi, K.. Role of ß112 Cys (G14) in homo-(ß4) and hetero-(a2ß2) tetramer hemoglobin formation. Journal of Biological Chemistry. Vol 273. 1998:14179-14185.