The Children's Hospital of Philadelphia
3501 Civic Center Blvd., Room CTRB4024
Philadelphia, PA, 19104


Centers of Emphasis: Childhood Cancer Research


Solid tumors in children, renal tumors in children, clinical pharmacology of anticancer drugs
Drug development for childhood cancers
Clinical pharmacology of anticancer drugs


Professor of Pediatrics at the Children's Hospital of Philadelphia (2009– present)


M.D., Medicine, Vanderbilt University (1975)

B.S., Zoology, University of North Carolina (1971)
Selected Publications
Fox Elizabeth, Widemann Brigitte C, Chuk Meredith K, Marcus Leigh, Aikin Alberta, Whitcomb Patricia O, Merino Maria J, Lodish Maya, Dombi Eva, Steinberg Seth M, Wells Samuel A, Balis Frank M. Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma. Clin Cancer Res. Vol 19(15) . 2013 Aug:4239-48.
Mossé Yael P, Lim Megan S, Voss Stephan D, Wilner Keith, Ruffner Katherine, Laliberte Julie, Rolland Delphine, Balis Frank M, Maris John M, Weigel Brenda J, Ingle Ashish M, Ahern Charlotte, Adamson Peter C, Blaney Susan M. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol. Vol 14(6) . 2013 May:472-80.
Widemann BC, Kim A, Fox E, Baruchel S, Adamson PC, Ingle AM, Glade-Bender J, Burke M, Weigel B, Stempak D, Balis FM Blaney SM.. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report. Clin Cancer Res. Vol 18(21) . 2013:6011-22.
Kim A, Dombi E, Tepas K, Fox E, Martin S, Wolters P, Balis FM, Jayaprakash N, Turkbey B, Muradyan N, Choyke PL, Korf B, Widemann BC.. Phase I trial and pharmacokinetic study of sorafenib in children with neurofibromatosis type I and plexiform neurofibromas. Pediatr Blood Cancer. Vol 60(3) . 2013:396-401.
Warren KE, Gururangan S, Geyer JR, McLendon RE, Poussaint TY, Wallace D, Balis FM, Berg SL, Packer RJ, Goldman S, Minturn JE, Pollack IF, Boyett JM, Kun LE.. A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high grade gliomas and brainstem gliomas: A Pediatric Brain Tumor Consortium Study.. J Neuro-Oncol. Vol 106. 2012:643-9.
Lodish M, Dagalakis U, Chen C, Sinaii N, Whitcomb T, Aikin A, Dombi E, Marcus L, Widemann B, Fox E, Chuk M, Balis FM, Wells S, Jr, Stratakis CA.. 111 In-Octreotide scintigraphy for identification of metastatic medullary thyroid carcinoma in children and adolescents. J Clin Endocrinol Metab. Vol 97. 2012:E207-12.
Murphy RF, Komlodi-Pasztor E, Robey R, Balis FM, Farrell NP, Fojo T.. Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum resistant cells compared to cisplatin and oxaliplatin. Cell Cycle. Vol 11. 2012:963-73.
Chuk MK, Aikin A, Whitcomb T, Widemann BC, Zannikos P, Beyever E, Balis FM, Fox E.. A phase I trial and pharmacokinetic study of a 24-hour infusion of trabectedin (Yondelis®, ET-743) in children and adolescents with relapsed or refractory solid tumors.. Pediatr Blood Cancer. Vol 59. 2012:865-9.
Kim A, McCully C, Cruz R, Cole DE, Fox E, Balis FM, Widemann BC.. The plasma and cerebrospinal fluid pharmacokinetics of sorafenib after intravenous administration in non-human primates. Invest New Drugs. Vol 30. 2012:524-8.
Balis FM, Fox E.. Challenges of developing new drugs for childhood cancers. Clin Investig. Vol 2. 2012:291-300.