ELIZABETH
  
LOWENTHAL
MD MSCE
Email: 
lowenthale@email.chop.edu
Address: 
3535 Market Street 15th Floor, Rm 1513
267-426-2306
Affiliations
Expertise

Dr. Lowenthal is a pediatric HIV specialist and clinical epidemiologist whose research work is primarily focused on Pediatric Global Health. In particular, most of her research relates to the care and treatment of children and adolescents with HIV in resource-limited settings. Her comparative effectiveness study of children receiving efavirenz-based or nevirapine-based antiretroviral therapy answered a question of great importance to the treatment of the more than 3 million HIV-infected children worldwide. Most of her current work is focused on adherence to HIV treatments among perinatally HIV-infected adolescents in Africa. Public health-focused aspects of her work are funded by a CDC-PEPFAR Public Health Effectiveness Grant and additional questions related to optimizing adherence measurement and defining developmental and psychosocial factors associated with non-adherence are funded by an NIH K23 Career Development award.

Dr. Lowenthal is involved with collaborative studies in multiple African countries. In addition, she is the co-PI for a pilot study assessing whether genetic differences in bitter taste receptors impact tolerability of a protease inhibitor drug used commonly for the treatment of HIV-infected infants.

Dr. Lowenthal is a pediatrician with expertise in HIV care of children and adolescents. Between 2004 and 2008, she was the clinic director of the Botswana-Baylor Children's Clinical Centre of Excellence (Botswana, Africa), providing care and treatment for over 1500 HIV-infected children and adolescents. She is currently a staff physician at the Special Immunology Family Care Center of the University of Pennsylvania where she provides both general pediatric care and HIV-related care.

Adherence; Pediatrics; HIV/AIDS; Global Health

Categorical Data; Health Services Research; Multivariate Analysis; Survival Analysis; Cultural Adaptation; Validation of Assessment Tools

Dr. Lowenthal's research is focused on the care and treatment of HIV-infected children and adolescents. She is currently the Principal Investigator for an NIH Research Career Development Award through NIMH and a CDC-funded Public Health Effectiveness research study of adherence to antiretroviral therapies among HIV-infected adolescents in Botswana.

Appointments
Assistant Professor of Biostatistics and Epidemiology at University of Pennsylvania School of Medicine (2014– present)
Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (2011– present)
Education
MSCE, Epidemiology, University of Pennsylvania (2012)
MD, Medicine, Baylor College of Medicine (2000)
B.A., Biology, Augustana College (1995)
Selected Publications
Elizabeth Lowenthal, Sabrina Bakeera-Kitaka, Tafireyi Marukutira, Jennifer Chapman, Kathryn Goldrath, Rashida Ferrand. HIV infection in vertically-infected adolescents in sub-Saharan Africa: A review of the emerging challenges. Lancet ID. Vol in press. 2013.
Mburu G, Hodgson I, Kalibala S, Cataldo F, Lowenthal E, Ross D. Adolescent HIV Disclosure in Zambia: Barriers, Facilitators and Outcomes. Journal of the International AIDS Society. Vol in press. 2014.
Elizabeth Lowenthal, Kathy Lawler, Nurit Harari, Lesedi Moamogwe, Motshodi Masedi, Japhter Masunge, Bolefela Matome, Esther Seloilwe, and Robert Gross. Use of the Pediatric Symptom Checklist for Screening for Psychosocial Dysfunction in Botswana. Thari Ya Bana. (4) . UNICEF and the University of Botswana; 2013 November:in press.
Jessica Eby, Jennifer Chapman, Tafireyi Marukutira, Tebo Dipotso, Omphile Lepodisi, Ontibile Tshume, Keboletse Mokete, Elizabeth Lowenthal. "Electronic monitoring of adolescent adherence to antiretroviral therapy in Botswana: Impact of cleaning and capping medication event monitoring system (MEMS) data on the adherence-outcome relationship". Children's Hospital of Philadelphia Global Health Conference. 2013 November.
Maimouna Ndiaye,Peter Nyasulu, Hoang Nguyen, Elizabeth D Lowenthal, Robert Gross, Edward J Mills, Jean B Nachega. Rick factors for suboptimal antiretroviral therapy adherence in HIV-infected adolescents in Gaborone, Botswana: a pilot cross-sectional study. Patient Preference and Adherence. Vol 7. Dovepress; 2013 September:891-895.
Elizabeth Lowenthal, Keboletse Mokete, Tafireyi Marukutira, Ontibile Tshume, Jennifer Chapman, Robert Gross, Karen Glanz. Establishing Construct Validity of Psychosocial Assessment Tools for Use in HIV+ African Adolescents and Exploring Previously Under-appreciated Factors Related to Medication Adherence. SEISIDA/AIDS Impact conference Barcelona 2013. 2013 September.
Marc Callender, Elizabeth Lowenthal, Rodney Finalle, Maura Murphy, James Guevara. Exploring Paternal Engagement in the Dominican Republic. Pediatric Academic Societies Annual Meeting. 2013 May.
Elizabeth D Lowenthal, Jonas H Ellenberg, Edwin Machine, Aditi Sagdeo, Sefalani Boiditswe, Andrew P. Steenhoff, Richard Rutstein, Gabriel Anabwani, Robert Gross. Association Between Efavirenz-Based Compared with Nevirapine-Based Antiretroviral Regimens and Virologic Failure in HIV-Infected Children. JAMA. Vol 309(17) . 2013 May:1803-1809.
Katherine Riva, Seipone Mphele, Elizabeth Lowenthal. Factors Affecting Alcohol and Drug Use among Secondary School Students in Botswana. Doris Duke Clinical Research Fellows Annual Conference. 2013 May.