- Affinity Groups:
Genes,Genomics and Pediatric Disease
- Centers of Emphasis:
Developmental Biology and Pediatric Disorders
Cardiovascular Institute Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Cardiovascular Institute Research Description:
The focus of my research from 1994 through 2007 was developmental biology of the cardiovascular system using the zebrafish model, with the overall goal of understanding the molecular basis of congenital heart disease.
My lab's main project was understanding how the left-right body axis was specified during embryonic development, in order to gain insight into a syndrome called heterotaxy, occurring at a frequency of 1.00 to 1.44 per 10,000 human live births. Disorders of organ lateralization, such as heterotaxy syndrome and situs inversus totalis, are frequently associated with complex anomalies of the heart and major veins. Despite elaborate staged surgical reconstructive strategies (usually culminating in the Fontan operation), 20-year survival remains
vertebrate developmental biology, especially the cardiovascular system;
congenital heart disease;
- Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1984 – 1989)
- Associate Professor of Pediatrics at the Children's Hospital of Philadelphia (1989 – 2002)
- Professor of Pediatrics at the Children's Hospital of Philadelphia (2002 – 2014)
- Emeritus Professor CE of Pediatrics at University of Pennsylvania School of Medicine (2014– present)
- M.D., medicine, Stanford University School of Medicine (1977)
- A.B., Biochemical Sciences, Harvard College (1973)
- Alvin J. Chin. Heterotaxy Syndrome and Primary Ciliary Dyskinesia. http://emedicine.medscape.com/article/896757-overview. 2012 June.
- V. Ramesh Iyer MD, Alvin J. Chin MD. Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). American Journal of Medical Genetics Part C. Vol 163C. 2013 August:185-197.
- Chin, AJ. Single Ventricle. http://emedicine.medscape.com/article/898559-overview. 2013 August.
- Chin, AJ. Interrupted aortic arch. http://emedicine.medscape.com/article/896979-overview. 2013 August.
- Joseph T. C. Shieh, John L. Jefferies, Alvin J. Chin. Disorders of Left Ventricular Trabeculation/Compaction or Right Ventricular Wall Formation. American Journal of Medical Genetics Part C. Vol 163C. 2013 August:141-143.