Alan
 
W.
 
Flake
Email: 
flake@email.chop.edu
Address: 
Department of Surgery Children?s Hospital of Philadelphia Abramson Research Center, Rm. 1102D 3516 Civic Center Blvd.
2155902753
Affiliations
Expertise

Prenatal stem cell and gene therapy, Stem cell biology, fetal surgery

Appointments
Associate Professor of Obstetrics and Gynecology at University of Pennsylvania School of Medicine (1997 – 2001)
Associate Professor of Surgery at University of Pennsylvania School of Medicine (1997 – 2002)
Professor of Surgery at University of Pennsylvania School of Medicine (2002– present)
Education
M.D., University of Arkansas for Medical Sciences, Little Rock, AR (1981)
B.S., University of Arkansas, Fayetteville (1977)
Selected Publications
Danzer Enrico, Victoria Teresa, Bebbington Michael W, Siegle Jennifer, Rintoul Natalie E, Johnson Mark P, Flake Alan W, Adzick N Scott, Hedrick Holly L. Fetal MRI-Calculated Total Lung Volumes in the Prediction of Short-Term Outcome in Giant Omphalocele: Preliminary Findings.. Fetal Diagnosis and Therapy. Vol 31(4) . 2012:248-53.
Roybal Jessica L, Endo Masayuki, Buckley Suzanne M K, Herbert Bronwen R, Waddington Simon N, Flake Alan W. Animal models for prenatal gene therapy: rodent models for prenatal gene therapy.. Methods in Molecular Biology (Clifton, N.J.). Vol 891. 2012:201-18.
Roybal Jessica L, Laje Pablo, Vrecenak Jesse D, Flake Alan W. Use of manipulated stem cells for prenatal therapy.. Methods in Molecular Biology (Clifton, N.J.). Vol 891. 2012:169-81.
Partridge Emily A, Flake Alan W. Maternal-fetal surgery for structural malformations.. Best Practice & Research. Clinical Obstetrics & Gynaecology. 2012 Apr.
Tsai Jacqueline, Sulkowski Jason, Adzick N Scott, Hedrick Holly L, Flake Alan W. Patch repair for congenital diaphragmatic hernia: is it really a problem?. Journal of Pediatric Surgery. Vol 47(4) . 2012 Apr:637-41.
Davey M G, Zoltick P W, Todorow C A, Limberis M P, Ruchelli E D, Hedrick H L, Flake A W. Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung.. Gene Therapy. Vol 19(2) . 2012 Feb:201-9.
Endo M, Zoltick P W, Radu A, Jiang Q, Matsui C, Marinkovich P M, McGrath J, Tamai K, Uitto J, Flake A W. Early intra-amniotic gene transfer using lentiviral vector improves skin blistering phenotype in a murine model of Herlitz junctional epidermolysis bullosa.. Gene Therapy. Vol 19(5) . 2011 Oct:561-9.
Roybal Jessica L, Moldenhauer Julie S, Khalek Nahla, Bebbington Michael W, Johnson Mark P, Hedrick Holly L, Adzick N Scott, Flake Alan W. Early delivery as an alternative management strategy for selected high-risk fetal sacrococcygeal teratomas.. Journal of pediatric surgery. Vol 46(7) . 2011 Jul:1325-32.
Santore Matthew T, Deans Katherine J, Behar Brittany J, Blinman Thane A, Adzick N Scott, Flake Alan W. Laparoscopic hepaticoduodenostomy versus open hepaticoduodenostomy for reconstruction after resection of choledochal cyst.. Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. Vol 21(4) . 2011 May:375-8.
Davey Marcus G, Flake Alan W. Genetic therapy for the fetus: a once in a lifetime opportunity.. Human Gene Therapy. Vol 22(4) . 2011 Apr:383-5.