EXEMPLAR PROJECTS CONDUCTED AND PUBLICATIONS

Myc and Cancer Metabolism

  1. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19345-50.

  2. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC. Nature. 2014 Sep 11;513(7517):251-5.

Neuroscience

  1. Dietary branched chain amino acids ameliorate injury-induced cognitive impairment. Cole JT, Mitala CM, Kundu S, Verma A, Elkind JA, Nissim I, Cohen AS. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):366-71.

  2. Brain amino acid requirements and toxicity: the example of leucine. Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S.

Diabetes

  1. Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine. Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A. J Biol Chem. 2013 Feb 8;288(6):3938-51.

  2. Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt. Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, Nissim I, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM. J Biol Chem. 2008 Jun 20;283(25):17238-49.

Lysosomal metabolism and autophagy

  1. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. Cell. 2013 Feb 14;152(4):778-90.

Impact of drug(s) on metabolome and fluxome

  1. The molecular and metabolic influence of long term agmatine consumption. Nissim I, Horyn O, Daikhin Y, Chen P, Li C, Wehrli SL, Nissim I, Yudkoff M. J Biol Chem. 2014 Apr 4;289(14):9710-29.

  2. Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM. Biochem J. 2012 Jun 15;444(3):537-51.

  3. Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, Gasser DL. EMBO Mol Med. 2011 Jul;3(7):410-27.

Urea cycle defect and inherted errors of metabolism

  1. Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. Hu C, Tai DS, Park H, Cantero-Nieto G, Chan E, Yudkoff M, Cederbaum SD, Lipshutz GS. Gene Ther. 2014 Dec 4. doi: 10.1038/gt.2014.106. [Epub ahead of print]

  2. Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate. Ah Mew N, McCarter R, Daikhin Y, Lichter-Konecki U, Nissim I, Yudkoff M, Tuchman M. J Pediatr. 2014 Aug;165(2):401-403.