The Children's Hospital of Philadelphia and the Beijing Genomics Institute (BGI) have formed a collaborative genome center entitled BGI@CHOP. Together, these elements form The High-throughput Sequencing (HTS) Core with increased capacity, expertise and analytical resources for conducting next-generation sequencing studies. The HTS Core will provide automated library construction and high-quality, high-throughput sequencing services for whole genome, whole exome, target region sequencing, transcriptome and RNA-Seq samples (SeeServices and Pricing for details and for other sequencing applications). Standard services include 100 x 100 paired-end runs on HiSeq 2000 instruments with basic bioinformatic analysis to assess run quality and to identify variants. The HiSeq 2000 instruments in the center are being upgraded to HiSeq 2500.