May 2013

“Our sizeable genetic database of African American children played a crucial role in this study, lending further support to the loci initially detected in the adult cohorts.”- Struan Grant, PhD

CHOP Awarded $3.1 Million Grant to Fund Behavioral Interventions Study

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A failure to address the emotional and behavioral problems of school-age children can have serious, life-changing ramifications, including poor grades, suspension and expulsion, and problems with the law later in life. However, studies show that only 1 in 5 children with emotional and behavioral disorders receive mental health services, with low-income and ethnically diverse children lagging far b …

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CHOP Cardiologist Helps Discover a Cause for Abnormal Heart Vessels

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A pediatric cardiologist at The Children’s Hospital of Philadelphia is a first author of new research identifying a mutation that disrupts the formation of veins bringing blood to the heart very early in development. The abnormal connections and blood flow result in so-called “blue babies” — newborns with a potentially deadly heart condition. Karl Degenhardt, MD, PhD, of the Cardiac Center at Chil …

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Study Identifies BMI-Associated Loci in Individuals of African Descent

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The United States has a weight problem: according to the CDC, more than one-third of American adults are obese. Moreover, as of 2010 one-third of children were either overweight or obese, with the rates of obesity doubling in children and tripling in adolescents in the past thirty years. And some groups are more inclined to be obese than others, with non-hispanic blacks 51 percent more likely than …

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Muscular Dystrophy Association Grant Could Lead to New Treatment

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A new grant award will allow an investigator from The Children’s Hospital of Philadelphia to study the effectiveness of certain drugs called retinoid agonists in slowing or preventing muscle degeneration in individuals with muscular dystrophy. Findings from the study could lead to a new, ground-breaking treatment for those individuals. Muscular dystrophy is a group of genetic disorders that causes …

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Drexel Undergrad, CHOP Advisor Present Brain Research on Capitol Hill

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A Drexel University undergraduate, accompanied by her CHOP faculty advisor, recently had the opportunity to present her traumatic brain injury research to a group of elected officials in Washington, D.C. at Posters on the Hill. Organized by the Council on Undergraduate Research (CUR), this annual event gives undergraduate investigators the chance to share their work directly with members of Congre …

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New Study Offers Biliary Atresia Clues

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A new genetic study by The Children’s Hospital of Philadelphia researchers may shed light on the causes of the rare childhood disease biliary atresia. The leading cause of liver transplantation in children, biliary atresia (BA) is a rare, life-threatening condition in which the ducts that carry bile from the liver to the gallbladder become blocked. Children’s Hospital’s Randy Matthews, MD, PhD, le …

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CHOP Scientist Contributes to Heart Defect Study

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A physician-scientist from The Children’s Hospital of Philadelphia, Elizabeth Goldmuntz, MD, is one of the senior leaders of a research consortium reporting important gene changes that may help explain why children are born with heart defects. CHOP is one of five centers in the Pediatric Cardiac Genetics Consortium, supported by the National Heart, Lung and Blood Institute, part of the National In …

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Children’s Hospital Autism Expert Consulted for Placenta Study Coverage

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Tara Wenger, MD, PhD, a Pediatric Genetics fellow in the Center for Autism Research, was recently featured in a number of articles about an exciting new study of autism. The study examined whether trophoblast inclusions — microscopic, abnormal folds in the tissue of the placenta — could serve as a predictor of autism in children from families at high risk for autism spectrum disorder (ASD). The st …

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Converting Stem Cells to Brain Cells Sheds Light on Neural Development

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Stem cells have the unique ability to develop, or differentiate, into other kinds of cells in the body. Researchers have now manipulated human stem cells so that they produce the types of brain cells that play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia, and autism. This new model cell system will allow neuroscientists to investigate normal brain development, as …

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Cancer Expert Honored with Pediatric Oncology Award and Lecture

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A pediatric oncologist with the Cancer Center at The Children’s Hospital of Philadelphia recently received a national award highlighting his lifetime research on neuroblastoma, the most common solid tumor of childhood. The American Society of Clinical Oncology conferred one of its highest awards on Garrett M. Brodeur, MD, who received the Pediatric Oncology Award and delivered the Pediatric Oncolo …

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CHOP, Penn Gene Therapy Trial for Blindness Honored

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A groundbreaking clinical trial of gene therapy for a form of congenital blindness, sponsored by The Children’s Hospital of Philadelphia in collaboration with Penn Medicine, was recently recognized with the Distinguished Clinical Research Achievement Award from the Clinical Research Forum, an organization of clinical research centers, industry, and volunteer groups. Based in Washington, D.C., the  …

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Requesting Applications for the 2014 Pew Scholars Program in Biomedical Sciences

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We are pleased to solicit internal applications to be considered for the 2014 Pew Scholars Program in Biomedical Sciences. The Pew Scholars Program provides funding to young investigators of outstanding promise in science relevant to the advancement of human health. The candidates are individuals who are in their first few years of their appointment at the assistant professor level. The award prov …

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