January 2014

“Multidisciplinary collaborations like this, that help researchers share findings and speed investigations, will help move innovative research from the bench to bedside and improve the care of children and families worldwide.”- Philip R. Johnson, MD

Flipping Gene Switch Could Lead to Sickle Cell Disease Treatment


Hematology researchers at Children’s Hospital have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period. Because this fetal hemoglobin is unaffected by the genetic defect in sickle cell disease (SCD), the cell culture findings may open the door to a new therapy for the debilitating blood disorder. “Our study shows the power …

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Project Seeks to Understand Molecular Mechanisms That Cause Aging


It’s no secret that as we age, our bodies change. Though the signs of aging — from wrinkles to graying hair to changes in metabolism — vary from person to person, the truth is that every day everyone is getting a little bit older. And the aging process, as we also know, can have implications for our health. As the National Institute on Aging (NIA) succinctly puts it, “getting older can come with a …

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Defining The Future: The 2013 CHOP Research Annual Report


In many ways, 2013 was a banner year for The Children’s Hospital of Philadelphia and the Research Institute. We achieved a number of firsts, notably being named the best children’s hospital in the country by both U.S. News & World Report and Parents magazine. And in April it was announced that the Research Institute received more NIH funding than any other independent children’s hospital. Thes …

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CHOP-Led Research Network Set to Join National Clinical Research Network


A network of children’s hospitals, data partners, and specialty networks led by Children’s Hospital was recently approved for an award from the Patient-Centered Outcomes Research Institute (PCORI) to develop and expand its work as part of PCORnet: the National Patient-Centered National Clinical Research Network. PEDSnet, A National Pediatric Learning Health System, was one of 28 multi-institutiona …

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How Can Common Organisms Cause Disease?


The human body is a crowded place. In addition to the many human cells — which number approximately 37.2 trillion, according to a recent Annals of Human Biology paper — there are many, many more microbial cells that live in our bodies. Indeed, the NIH’s Human Microbiome Project notes “microbial cells are estimated to outnumber human cells ten to one,” including many that are commensal and live in  …

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CHOP, Drexel Consortium to Boost Pediatric Medical Device Pipeline


For medical devices, as with many medicines, the market for children is a small fraction of the adult market, and there are far fewer child-sized devices. But the need for pediatric medical devices exists, even if proper devices may not. “It’s not simply a matter of scaling down adult equipment for pediatric use,” said Children’s Hospital bioengineer Matthew Maltese, PhD. “Pediatricians have long  …

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Junior Investigator Grant Proposals Now Being Accepted


The Clinical and Translational Research Center is now accepting research proposals to be considered for the Junior Investigator Preliminary/Feasibility Grant Program. The primary goal of the Clinical Translational Research Center Junior Investigator Preliminary/Feasibility Grant Program is to encourage junior investigators to develop clinical research projects that will ultimately lead to extramur …

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Share Your Story!


The success stories from CHOP Research are incredible. They have the power to connect investigators who can combine unique approaches for enhanced success, inspire donors to contribute the resources necessary to take a project to its next step, and provide hope for families struggling with childhood disease. Sharing your story is essential so that we can spread the word about the amazing, groundbr …

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