August 2013

“Injury is the leading health risk for children and young adults. Proven prevention strategies and appropriate acute care will reduce fatalities and the long-term consequences that injury can have on quality of life.”- Flaura K. Winston, MD, PhD

Presentation, Not Treatment, Responsible for Racial Disparity in Breast Cancer Survival


Researchers from The Children’s Hospital of Philadelphia and the University of Pennsylvania recently published a study in the Journal of the American Medical Association (JAMA) that shows differences in how breast cancer patients present at diagnosis are more responsible for racial disparities in 5-year survival than treatment disparities. Jeffrey H. Silber, MD, PhD, professor of Pediatrics, Anest …

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CHOP Researchers Advance New Anti-Tumor Immunotherapy Approach


By carefully adjusting the function of crucial immune cells, Children’s Hospital investigators may have developed a completely new type of cancer immunotherapy, which involves harnessing the body’s immune system to attack tumors. To accomplish this, they had to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune responses. The new research, performed in anim …

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Widespread Healthcare Access Could Lead to Influx of Pediatric Patients


New research signals that emergency and outpatient healthcare providers may need to prepare for higher demand for treatment among younger patients with mild and moderate injuries. As policies encouraging broader health insurance coverage go into effect, researchers estimate the potential for more than 730,000 additional medically attended injuries annually, or a 6.1 percent increase if all current …

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Current Techniques to Prevent Lung Injury in Babies Less Effective than Expected


A Children’s Hospital neonatologist is the senior author of a new study showing current non-invasive techniques for respiratory support are less effective than assumed in reducing the incidence of severe lung injury in very premature infants. Neonatologists commonly use non-invasive nasal ventilation instead of mechanical ventilation via a breathing tube, in hopes of avoiding bronchopulmonary dysp …

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St. Baldrick’s Foundation Awards Children’s Hospital More than $650,000


The St. Baldrick’s Foundation recently announced $699,186 in grants to one consortium and three cancer researchers at Children’s Hospital. The foundation made awards to the Testicular Cryopreservation Consortium and to investigators Shannon Maude, MD, PhD, Michael Hogarty, MD, and Vandana Batra, MD. Known for its head-shaving events — where volunteers have their heads shaved in solidarity with chi …

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Training Program Seeks to Confront Neurodevelopmental Disabilities


Roughly 10 percent of American households live with an individual with a neurodevelopmental disability, every day grappling with the emotional, logistical, and financial burdens brought on by these conditions. Specifically, 2010 data from the U.S. Census shows that approximately 1.2 million American adults, or 0.5 percent of the population, had an intellectual disability or mental retardation, whi …

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Reprogramming Stem Cells Offers Powerful Tool for Studying, Treating Diseases


First produced in the past decade, human induced pluripotent stem cells are capable of developing into many or even all human cell types. In new research, scientists reprogrammed skin cells from patients with rare blood disorders into induced pluripotent stem cells (iPSCs), highlighting the great promise of these cells in advancing understanding of those challenging diseases — and eventually in tr …

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Children’s Hospital Investigators Discover Mitochondrial Signaling Response


Mitochondria are tiny biological structures that act as our cell’s power plants, extracting energy from nutrients to drive the body. When mitochondria malfunction, they may impair the function of potentially any organ in the body, in a bewildering variety of ways. Mitochondrial disease can have widely varying effects and severity, ranging from blindness to exercise intolerance to death, often wrea …

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Share Your Story!


The success stories from CHOP Research are incredible. They have the power to connect investigators who can combine unique approaches for enhanced success, inspire donors to contribute the resources necessary to take a project to its next step, and provide hope for families struggling with childhood disease. Sharing your story is essential so that we can spread the word about the amazing, groundbr …

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