“If clinicians can reposition existing drugs to treat some patients with hypertension, this will save significant time in drug development, as they won’t be starting development from scratch.”

- Brendan J. Keating, DPhil

Blood Pressure Signals Could Offer Drug Targets

The list of genes affecting blood pressure is expanding, as researchers pursue likely targets for therapeutics already in existence or in development. A Children’s Hospital researcher collaborated wit …

Study Reports Preterm Infant Tracheostomy Outcomes

Neonatologists at The Children’s Hospital of Philadelphia frequently face the difficult decision of whether to place a tracheostomy in a preterm infant with severe lung disease and when to do it. But  …

Retinopathy of Prematurity Associated With Disabilities

A study led by a CHOP neonatology expert showed that infants with severe retinopathy of prematurity (ROP) diagnosed and treated under modern protocols remain at risk of nonvisual disabilities, even if …

Donation Creates Penn, CHOP Center of Excellence

Three longtime allies have joined forces to create the new Penn Medicine/CHOP Friedreich’s Ataxia Center of Excellence. The establishment of the center was catalyzed by a $3.25 million gift from the F …

Genetic Signals Linking Weight, Heart Risk Factors Found

Two recent studies, both co-led by The Children’s Hospital of Philadelphia’s Brendan J. Keating, DPhil, expand the list of genes involved with body fat and body mass index, and their connection to hea …

As One Food Allergy Resolves, Another May Develop

Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. A new study by pediatric allergy experts suggests that h …

Paper Explores Endoplasmic Reticulum Stress Response

By shedding light on how cells deal with stress, a new study led by The Children’s Hospital of Philadelphia’s Yair Argon, PhD, could lay the foundations for future therapies. The study, which identifi …

Gene Sequencing Test to Speed Donor Matching, Research

Immunogenetics experts at The Children’s Hospital of Philadelphia have developed a unique laboratory test to characterize the genes that encode HLA molecules. The test relies on faster, more comprehen …

Campaign Raises Pediatric Palliative Care Awareness

Pediatric palliative care is a powerful intervention that can be prescribed alongside curative or life-prolonging therapies for children with serious illnesses. Research has shown that pediatric palli …

CHOP Research Honors Distinguished Trainees

During The Children’s Hospital of Philadelphia Research Institute’s recent Poster Day event, the 2014 Distinguished Research Trainee Award winners were announced. Comprised of a physicist, a molecular …

Pediatric Psychology Experts Set to Shine at SPPAC

Pediatric psychology is a key component of family-centered care at The Children’s Hospital of Philadelphia. When a child has a serious or chronic illness, pediatric psychologists listen carefully and  …

Congratulations to the 2014 Poster Day Award Winners!

The Children’s Hospital of Philadelphia Research Institute celebrated its 24th CHOP Research Poster Day on February 26, 2014, with more than 160 cutting-edge research posters on display in the Colket  …