“It is exciting to see the big consortia put the genomic data of almost 400 patients together. This clearly highlights that by working together we can find new genes faster, helping us to explain what causes this often devastating disease in children.”

- Tracy Dixon-Salazar, PhD

Pioneering T-Cell Therapy Leads to Remarkable Remission Rate

A landmark new study published in the New England Journal of Medicine shows that 90 percent of leukemia patients treated with a groundbreaking form of cellular therapy achieved complete responses. Led …

International Study Pinpoints Childhood Epilepsy Genes

An international team of researchers recently identified gene mutations that can cause severe, difficult-to-treat forms of childhood epilepsy. Many of the mutations disrupt functioning in the synapse, …

Increases in Mitochondrial DNA Mutations Can Cause Shifts in Disease

Recent work by a mitochondrial medicine pioneer from The Children’s Hospital of Philadelphia details how subtle changes in mitochondrial function may cause a broad range of common metabolic and degene …

To Maintain Appropriate Antibiotic Use, Sustained Feedback Needed

A program that provides guidance to primary care physicians about appropriately prescribing antibiotics for children is effective, but its improvements wear off after regular auditing and feedback are …

CIRP Research Improves Teen Driving Training, Assessment

A recent article in the Wall Street Journal on “one of the most dreaded rites of child-rearing — teaching a teenager to drive,” notes recent research on teen driving and training can help teens learn  …

Safety of Severe Asthma Care Outside the ICU Assessed

Clinicians at The Children’s Hospital of Philadelphia have extensive experience in treating children with acute asthma flares, partly due to the tremendous volume of patients with this respiratory con …

Rescuing Mutation May Operate in Bone Marrow Failure

Bone marrow failure syndromes are rare disorders in which the bone marrow does not produce enough blood cells, increasing the risk for life-threatening bleeding, anemia, and infections. While children …

Antibiotic Use in Infancy May Play Role in Obesity

While it is easy to blame the childhood obesity epidemic on too many french fries and video games, it is likely that multiple factors such as genetics and environment also contribute to excessive weig …

Research Funding Shortfalls Require Personal Response

The Children’s Hospital of Philadelphia’s Peter M. Grollman, vice president of CHOP’s Office of Government Affairs, Community Relations, and Advocacy recently penned a powerful editorial on Philly.com …

Children’s Hospital Researchers Honored

Four researchers from The Children’s Hospital of Philadelphia were recently honored with awards from the Perelman School of Medicine at the University of Pennsylvania. The 2014 Penn Medicine Awards of …

Core Seeks to Ease Recruitment Process

As the saying goes, it takes a village: without patients who believe in the promise that clinical research offers, medical studies can be doomed to fail. While every investigation is the product of ha …