Category Archive: Center for Applied Genomics

Apr 22 2014

Rare Disease Project Makes Progress, Empowers

In the U.S., a disease is considered rare if it affects fewer than 200,000 people. Many rare diseases have genetic origins, and almost 70 percent of Americans affected by a rare disease are children, according to the National Organization for Rare Disorders (NORD).

Permanent link to this article: http://www.research.chop.edu/blog/rare-disease-project-makes-progress-empowers/

Apr 17 2014

Studies Find Genes Linked to BMI, Cardiovascular Health

Two recent studies expand the list of genes associated with body fat and body mass index (BMI), and their connection to heart disease, high blood pressure, and diabetes.

Permanent link to this article: http://www.research.chop.edu/blog/studies-find-genes-linked-bmi-cardiovascular-health/

Mar 06 2014

New Gene Signals Likely Blood Pressure Drug Targets

The list of genes affecting blood pressure is expanding, as researchers pursue likely targets for therapeutics already in existence or in development.

Permanent link to this article: http://www.research.chop.edu/blog/new-gene-signals-likely-blood-pressure-drug-targets/

Jan 09 2014

CHOP Genetics Expert Edits Book Examining Genetics and Obesity

A recently published book edited by The Children’s Hospital of Philadelphia’s Struan F.A. Grant, PhD, examines the role genetic variants play in causing or raising the risk of obesity.

Permanent link to this article: http://www.research.chop.edu/blog/chop-genetics-expert-edits-book-examining-genetics-obesity/

Nov 21 2013

International Team Discovers Childhood Asthma Gene

An international team of researchers, including several investigators from The Children’s Hospital of Philadelphia’s Center for Applied Genomics, recently discovered a gene associated with a high risk of severe childhood asthma.

Permanent link to this article: http://www.research.chop.edu/blog/international-team-discovers-childhood-asthma-gene/

Sep 26 2013

African American Blood Pressure Study Identifies New Gene Variants

A new study detailing the largest-ever genetic analysis of blood pressure in African Americans has identified five gene variants linked to the trait.

Permanent link to this article: http://www.research.chop.edu/blog/african-american-blood-pressure-study-identifies-new-gene-variants/

Jul 23 2013

Penn Team Finds Immune Cells Promote Food-Allergy Associated Inflammation

A team from the Perelman School of Medicine at the University of Pennsylvania recently published a study in Nature Medicine that sheds light on food allergy-associated inflammation.

Permanent link to this article: http://www.research.chop.edu/blog/penn-team-finds-immune-cells-promote-food-allergy-associated-inflammation/

May 17 2013

Study Identifies BMI-Associated Loci in Individuals of African Descent

Struan Grant, PhD, associate director of The Children’s Hospital of Philadelphia’s Center for Applied Genomics (CAG), co-authored a study that discovered new loci associated with body mass index (BMI) in adults of African ancestry.

Permanent link to this article: http://www.research.chop.edu/blog/study-identifies-bmi-associated-loci-in-individuals-of-african-descent/

Feb 19 2013

Study Finds Link Between Genes and Lifespan

Several gene variants can influence a person’s potential lifespan by either raising the probability of developing a disease or by providing protection from disease, according to new research from The Children’s Hospital of Philadelphia.

Permanent link to this article: http://www.research.chop.edu/blog/chop-study-finds-link-between-genes-and-lifespan/

Jan 16 2013

CHOP Researchers Find New Gene Variants Related to Autism Spectrum Disorders

Genetics researchers at The Children’s Hospital of Philadelphia have found 25 “high impact” gene variants that occur in some patients with autism. Although rare individually, each genetic variant has a strong effect in raising a person’s autism risk. These findings could be incorporated into clinical tests for evaluating children for autism spectrum disorders.

Permanent link to this article: http://www.research.chop.edu/blog/chop-researchers-find-new-gene-variants-related-to-autism-spectrum-disorders-2/